Forty-five years of cell-cycle genetics

In the early 1970s, studies in Leland Hartwell’s laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps...

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Detalles Bibliográficos
Autores principales: Reid, Brian J., Culotti, Joseph G., Nash, Robert S., Pringle, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Retrospective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666127/
https://www.ncbi.nlm.nih.gov/pubmed/26628751
http://dx.doi.org/10.1091/mbc.E14-10-1484
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author Reid, Brian J.
Culotti, Joseph G.
Nash, Robert S.
Pringle, John R.
author_facet Reid, Brian J.
Culotti, Joseph G.
Nash, Robert S.
Pringle, John R.
author_sort Reid, Brian J.
collection PubMed
description In the early 1970s, studies in Leland Hartwell’s laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homologues.
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spelling pubmed-46661272016-02-16 Forty-five years of cell-cycle genetics Reid, Brian J. Culotti, Joseph G. Nash, Robert S. Pringle, John R. Mol Biol Cell Retrospective In the early 1970s, studies in Leland Hartwell’s laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homologues. The American Society for Cell Biology 2015-12-01 /pmc/articles/PMC4666127/ /pubmed/26628751 http://dx.doi.org/10.1091/mbc.E14-10-1484 Text en © 2015 Reid et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
spellingShingle Retrospective
Reid, Brian J.
Culotti, Joseph G.
Nash, Robert S.
Pringle, John R.
Forty-five years of cell-cycle genetics
title Forty-five years of cell-cycle genetics
title_full Forty-five years of cell-cycle genetics
title_fullStr Forty-five years of cell-cycle genetics
title_full_unstemmed Forty-five years of cell-cycle genetics
title_short Forty-five years of cell-cycle genetics
title_sort forty-five years of cell-cycle genetics
topic Retrospective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666127/
https://www.ncbi.nlm.nih.gov/pubmed/26628751
http://dx.doi.org/10.1091/mbc.E14-10-1484
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