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Induced oligomerization targets Golgi proteins for degradation in lysosomes

Manganese protects cells against forms of Shiga toxin by down-regulating the cycling Golgi protein GPP130. Down-regulation occurs when Mn binding causes GPP130 to oligomerize and traffic to lysosomes. To determine how GPP130 is redirected to lysosomes, we tested the role of GGA1 and clathrin, which...

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Detalles Bibliográficos
Autores principales:	Tewari, Ritika, Bachert, Collin, Linstedt, Adam D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666137/ https://www.ncbi.nlm.nih.gov/pubmed/26446839 http://dx.doi.org/10.1091/mbc.E15-04-0207

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