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Emergence of clonal chromosomal alterations during the mesenchymal stromal cell cultivation

BACKGROUND: Use of human mesenchymal stromal cells (MSCs) is a promising strategy for cell therapy in injured tissues recovery. However, MSCs acquire genetic changes when cultivated in vitro that make them more susceptible to undergo neoplastic transformation. Therefore, genomic integrity of stem ce...

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Detalles Bibliográficos
Autores principales:	Borgonovo, Tamara, Solarewicz, Maria Marlene, Vaz, Isadora May, Daga, Debora, Rebelatto, Carmen Lúcia Kuniyoshi, Senegaglia, Alexandra Cristina, Ribeiro, Enilze, Cavalli, Iglenir João, Brofman, Paulo Slud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666177/ https://www.ncbi.nlm.nih.gov/pubmed/26628918 http://dx.doi.org/10.1186/s13039-015-0197-5

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