Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage

BACKGROUND: Traumatic brain injury can trigger chronic neuroinflammation, which may predispose to neurodegeneration. Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this relationship has never been shown in vivo. FIN...

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Autores principales: Scott, Gregory, Hellyer, Peter J., Ramlackhansingh, Anil F., Brooks, David J., Matthews, Paul M., Sharp, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666189/
https://www.ncbi.nlm.nih.gov/pubmed/26627199
http://dx.doi.org/10.1186/s12974-015-0445-y
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author Scott, Gregory
Hellyer, Peter J.
Ramlackhansingh, Anil F.
Brooks, David J.
Matthews, Paul M.
Sharp, David J.
author_facet Scott, Gregory
Hellyer, Peter J.
Ramlackhansingh, Anil F.
Brooks, David J.
Matthews, Paul M.
Sharp, David J.
author_sort Scott, Gregory
collection PubMed
description BACKGROUND: Traumatic brain injury can trigger chronic neuroinflammation, which may predispose to neurodegeneration. Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this relationship has never been shown in vivo. FINDINGS: Using [(11)C]-PK11195 positron emission tomography, a marker of microglial activation, we previously demonstrated thalamic inflammation up to 17 years after traumatic brain injury. Here, we use diffusion MRI to estimate axonal injury and show that thalamic inflammation is correlated with thalamo-cortical tract damage. CONCLUSIONS: These findings support a link between axonal damage and persistent inflammation after brain injury.
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spelling pubmed-46661892015-12-02 Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage Scott, Gregory Hellyer, Peter J. Ramlackhansingh, Anil F. Brooks, David J. Matthews, Paul M. Sharp, David J. J Neuroinflammation Short Report BACKGROUND: Traumatic brain injury can trigger chronic neuroinflammation, which may predispose to neurodegeneration. Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this relationship has never been shown in vivo. FINDINGS: Using [(11)C]-PK11195 positron emission tomography, a marker of microglial activation, we previously demonstrated thalamic inflammation up to 17 years after traumatic brain injury. Here, we use diffusion MRI to estimate axonal injury and show that thalamic inflammation is correlated with thalamo-cortical tract damage. CONCLUSIONS: These findings support a link between axonal damage and persistent inflammation after brain injury. BioMed Central 2015-12-01 /pmc/articles/PMC4666189/ /pubmed/26627199 http://dx.doi.org/10.1186/s12974-015-0445-y Text en © Scott et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Scott, Gregory
Hellyer, Peter J.
Ramlackhansingh, Anil F.
Brooks, David J.
Matthews, Paul M.
Sharp, David J.
Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
title Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
title_full Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
title_fullStr Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
title_full_unstemmed Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
title_short Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
title_sort thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666189/
https://www.ncbi.nlm.nih.gov/pubmed/26627199
http://dx.doi.org/10.1186/s12974-015-0445-y
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