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High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing’s disease

OBJECTIVE: To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing’s disease. METHODS: In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a l...

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Autores principales: de Rotte, Alexandra A. J., Groenewegen, Amy, Rutgers, Dik R., Witkamp, Theo, Zelissen, Pierre M. J., Meijer, F. J. Anton, van Lindert, Erik J., Hermus, Ad, Luijten, Peter R., Hendrikse, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666272/
https://www.ncbi.nlm.nih.gov/pubmed/25991481
http://dx.doi.org/10.1007/s00330-015-3809-x
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author de Rotte, Alexandra A. J.
Groenewegen, Amy
Rutgers, Dik R.
Witkamp, Theo
Zelissen, Pierre M. J.
Meijer, F. J. Anton
van Lindert, Erik J.
Hermus, Ad
Luijten, Peter R.
Hendrikse, Jeroen
author_facet de Rotte, Alexandra A. J.
Groenewegen, Amy
Rutgers, Dik R.
Witkamp, Theo
Zelissen, Pierre M. J.
Meijer, F. J. Anton
van Lindert, Erik J.
Hermus, Ad
Luijten, Peter R.
Hendrikse, Jeroen
author_sort de Rotte, Alexandra A. J.
collection PubMed
description OBJECTIVE: To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing’s disease. METHODS: In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients. RESULTS: The interobserver agreement for lesion detection was good at 1.5 T MRI (κ = 0.69) and 7.0 T MRI (κ = 0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI. CONCLUSION: The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing’s disease was good, and lesions were detected more accurately with 7.0 T MRI. KEY POINTS: • Interobserver agreement for lesion detection on 1.5 T MRI was good; • Interobserver agreement for lesion detection on 7.0 T MRI was good; • 7.0 T enabled confirmation of unclear lesions at 1.5 T; • 7.0 T enabled visualization of lesions not visible at 1.5 T. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00330-015-3809-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-46662722015-12-09 High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing’s disease de Rotte, Alexandra A. J. Groenewegen, Amy Rutgers, Dik R. Witkamp, Theo Zelissen, Pierre M. J. Meijer, F. J. Anton van Lindert, Erik J. Hermus, Ad Luijten, Peter R. Hendrikse, Jeroen Eur Radiol Neuro OBJECTIVE: To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing’s disease. METHODS: In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients. RESULTS: The interobserver agreement for lesion detection was good at 1.5 T MRI (κ = 0.69) and 7.0 T MRI (κ = 0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI. CONCLUSION: The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing’s disease was good, and lesions were detected more accurately with 7.0 T MRI. KEY POINTS: • Interobserver agreement for lesion detection on 1.5 T MRI was good; • Interobserver agreement for lesion detection on 7.0 T MRI was good; • 7.0 T enabled confirmation of unclear lesions at 1.5 T; • 7.0 T enabled visualization of lesions not visible at 1.5 T. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00330-015-3809-x) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-05-20 2016 /pmc/articles/PMC4666272/ /pubmed/25991481 http://dx.doi.org/10.1007/s00330-015-3809-x Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Neuro
de Rotte, Alexandra A. J.
Groenewegen, Amy
Rutgers, Dik R.
Witkamp, Theo
Zelissen, Pierre M. J.
Meijer, F. J. Anton
van Lindert, Erik J.
Hermus, Ad
Luijten, Peter R.
Hendrikse, Jeroen
High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing’s disease
title High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing’s disease
title_full High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing’s disease
title_fullStr High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing’s disease
title_full_unstemmed High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing’s disease
title_short High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing’s disease
title_sort high resolution pituitary gland mri at 7.0 tesla: a clinical evaluation in cushing’s disease
topic Neuro
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666272/
https://www.ncbi.nlm.nih.gov/pubmed/25991481
http://dx.doi.org/10.1007/s00330-015-3809-x
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