A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation

Eukaryotic translation initiation factor eIF4AI, the founding member of DEAD-box helicases, undergoes ATP hydrolysis-coupled conformational changes to unwind mRNA secondary structures during translation initiation. However, the mechanism of its coupled enzymatic activities remains unclear. Here we r...

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Detalles Bibliográficos
Autores principales: Lu, Junyan, Jiang, Chenxiao, Li, Xiaojing, Jiang, Lizhi, Li, Zengxia, Schneider-Poetsch, Tilman, Liu, Jianwei, Yu, Kunqian, Liu, Jun O., Jiang, Hualiang, Luo, Cheng, Dang, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666354/
https://www.ncbi.nlm.nih.gov/pubmed/26464436
http://dx.doi.org/10.1093/nar/gkv1033

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