Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor

Optimizing bio-production involves strain and process improvements performed as discrete steps. However, environment impacts genotype and a strain that is optimal under one set of conditions may not be under different conditions. We present a methodology to simultaneously vary genetic and process fa...

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Detalles Bibliográficos
Autores principales: Zhou, Hui, Vonk, Brenda, Roubos, Johannes A., Bovenberg, Roel A.L., Voigt, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666358/
https://www.ncbi.nlm.nih.gov/pubmed/26519464
http://dx.doi.org/10.1093/nar/gkv1071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666358/
https://www.ncbi.nlm.nih.gov/pubmed/26519464
http://dx.doi.org/10.1093/nar/gkv1071

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