Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling

Defects in the ability to respond properly to an unrepaired DNA lesion blocking replication promote genomic instability and cancer. Human HLTF, implicated in error-free replication of damaged DNA and tumour suppression, exhibits a HIRAN domain, a RING domain, and a SWI/SNF domain facilitating DNA-bi...

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Detalles Bibliográficos
Autores principales: Achar, Yathish Jagadheesh, Balogh, David, Neculai, Dante, Juhasz, Szilvia, Morocz, Monika, Gali, Himabindu, Dhe-Paganon, Sirano, Venclovas, Česlovas, Haracska, Lajos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666394/
https://www.ncbi.nlm.nih.gov/pubmed/26350214
http://dx.doi.org/10.1093/nar/gkv896

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