Development and initial evaluation of a semi-automatic approach to assess perivascular spaces on conventional magnetic resonance images

PURPOSE: Perivascular spaces (PVS) are associated with ageing, cerebral small vessel disease, inflammation and increased blood brain barrier permeability. Most studies to date use visual rating scales to assess PVS, but these are prone to observer variation. METHODS: We developed a semi-automatic computational method that extracts PVS on bilateral ovoid basal ganglia (BG) regions on intensity-normalised T2-weighted magnetic resonance images. It uses Analyze™10.0 and was applied to 100 mild stroke patients’ datasets. We used linear regression to test association between BGPVS count, volume and visual rating scores; and between BGPVS count & volume, white matter hyperintensity (WMH) rating scores (periventricular: PVH; deep: DWMH) & volume, atrophy rating scores and brain volume. RESULTS: In the 100 patients WMH ranged from 0.4 to 119 ml, and total brain tissue volume from 0.65 to 1.45 l. BGPVS volume increased with BGPVS count (67.27, 95%CI [57.93 to 76.60], p < 0.001). BGPVS count was positively associated with WMH visual rating (PVH: 2.20, 95%CI [1.22 to 3.18], p < 0.001; DWMH: 1.92, 95%CI [0.99 to 2.85], p < 0.001), WMH volume (0.065, 95%CI [0.034 to 0.096], p < 0.001), and whole brain atrophy visual rating (1.01, 95%CI [0.49 to 1.53], p < 0.001). BGPVS count increased as brain volume (as % of ICV) decreased (−0.33, 95%CI [−0.53 to −0.13], p = 0.002). COMPARISON WITH EXISTING METHOD: BGPVS count and volume increased with the overall increase of BGPVS visual scores (2.11, 95%CI [1.36 to 2.86] for count and 0.022, 95%CI [0.012 to 0.031] for volume, p < 0.001). Distributions for PVS count and visual scores were also similar. CONCLUSIONS: This semi-automatic method is applicable to clinical protocols and offers quantitative surrogates for PVS load. It shows good agreement with a visual rating scale and confirmed that BGPVS are associated with WMH and atrophy measurements.