Cargando…

Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate

Fenofibrate belongs to hypolipidemic fibrates that act as activators of the peroxisome proliferator-activated receptor-α, a regulator of bile acid synthesis, metabolism and transport. The present study aimed at evaluating the effects of fenofibrate on the circulating bile acid profile in humans. Hun...

Descripción completa

Detalles Bibliográficos
Autores principales: Trottier, J., Caron, P., Straka, R. J., Barbier, O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666518/
https://www.ncbi.nlm.nih.gov/pubmed/21716269
http://dx.doi.org/10.1038/clpt.2011.124
_version_ 1782403716806082560
author Trottier, J.
Caron, P.
Straka, R. J.
Barbier, O.
author_facet Trottier, J.
Caron, P.
Straka, R. J.
Barbier, O.
author_sort Trottier, J.
collection PubMed
description Fenofibrate belongs to hypolipidemic fibrates that act as activators of the peroxisome proliferator-activated receptor-α, a regulator of bile acid synthesis, metabolism and transport. The present study aimed at evaluating the effects of fenofibrate on the circulating bile acid profile in humans. Hundred healthy men and women completed a 3-week intervention with fenofibrate, and 17 bile acid species were measured in serum samples drawn before and after fenofibrate treatment. Fenofibrate caused significant reductions in levels of chenodeoxycholic (−26.4%), ursodeoxycholic (−30.5%), lithocholic (−18.4%), deoxycholic (−22.3%) and hyodeoxycholic (−19.2%) acids. A gender-related difference was observed in the response of various bile acids and the total bile acid concentration was significantly reduced only in men (−18.6%), while remaining almost unchanged in women (+0.36%). This difference detected suggests that fenofibrate should be more efficient at reducing bile acid toxicity in men than in women in cholestatic liver diseases.
format Online
Article
Text
id pubmed-4666518
institution National Center for Biotechnology Information
language English
publishDate 2011
record_format MEDLINE/PubMed
spelling pubmed-46665182015-12-01 Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate Trottier, J. Caron, P. Straka, R. J. Barbier, O. Clin Pharmacol Ther Article Fenofibrate belongs to hypolipidemic fibrates that act as activators of the peroxisome proliferator-activated receptor-α, a regulator of bile acid synthesis, metabolism and transport. The present study aimed at evaluating the effects of fenofibrate on the circulating bile acid profile in humans. Hundred healthy men and women completed a 3-week intervention with fenofibrate, and 17 bile acid species were measured in serum samples drawn before and after fenofibrate treatment. Fenofibrate caused significant reductions in levels of chenodeoxycholic (−26.4%), ursodeoxycholic (−30.5%), lithocholic (−18.4%), deoxycholic (−22.3%) and hyodeoxycholic (−19.2%) acids. A gender-related difference was observed in the response of various bile acids and the total bile acid concentration was significantly reduced only in men (−18.6%), while remaining almost unchanged in women (+0.36%). This difference detected suggests that fenofibrate should be more efficient at reducing bile acid toxicity in men than in women in cholestatic liver diseases. 2011-06-29 2011-08 /pmc/articles/PMC4666518/ /pubmed/21716269 http://dx.doi.org/10.1038/clpt.2011.124 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Trottier, J.
Caron, P.
Straka, R. J.
Barbier, O.
Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate
title Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate
title_full Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate
title_fullStr Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate
title_full_unstemmed Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate
title_short Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate
title_sort profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666518/
https://www.ncbi.nlm.nih.gov/pubmed/21716269
http://dx.doi.org/10.1038/clpt.2011.124
work_keys_str_mv AT trottierj profileofserumbileacidsinnoncholestaticvolunteersgenderrelateddifferencesinresponsetofenofibrate
AT caronp profileofserumbileacidsinnoncholestaticvolunteersgenderrelateddifferencesinresponsetofenofibrate
AT strakarj profileofserumbileacidsinnoncholestaticvolunteersgenderrelateddifferencesinresponsetofenofibrate
AT barbiero profileofserumbileacidsinnoncholestaticvolunteersgenderrelateddifferencesinresponsetofenofibrate