Cargando…
Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate
Fenofibrate belongs to hypolipidemic fibrates that act as activators of the peroxisome proliferator-activated receptor-α, a regulator of bile acid synthesis, metabolism and transport. The present study aimed at evaluating the effects of fenofibrate on the circulating bile acid profile in humans. Hun...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666518/ https://www.ncbi.nlm.nih.gov/pubmed/21716269 http://dx.doi.org/10.1038/clpt.2011.124 |
_version_ | 1782403716806082560 |
---|---|
author | Trottier, J. Caron, P. Straka, R. J. Barbier, O. |
author_facet | Trottier, J. Caron, P. Straka, R. J. Barbier, O. |
author_sort | Trottier, J. |
collection | PubMed |
description | Fenofibrate belongs to hypolipidemic fibrates that act as activators of the peroxisome proliferator-activated receptor-α, a regulator of bile acid synthesis, metabolism and transport. The present study aimed at evaluating the effects of fenofibrate on the circulating bile acid profile in humans. Hundred healthy men and women completed a 3-week intervention with fenofibrate, and 17 bile acid species were measured in serum samples drawn before and after fenofibrate treatment. Fenofibrate caused significant reductions in levels of chenodeoxycholic (−26.4%), ursodeoxycholic (−30.5%), lithocholic (−18.4%), deoxycholic (−22.3%) and hyodeoxycholic (−19.2%) acids. A gender-related difference was observed in the response of various bile acids and the total bile acid concentration was significantly reduced only in men (−18.6%), while remaining almost unchanged in women (+0.36%). This difference detected suggests that fenofibrate should be more efficient at reducing bile acid toxicity in men than in women in cholestatic liver diseases. |
format | Online Article Text |
id | pubmed-4666518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
record_format | MEDLINE/PubMed |
spelling | pubmed-46665182015-12-01 Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate Trottier, J. Caron, P. Straka, R. J. Barbier, O. Clin Pharmacol Ther Article Fenofibrate belongs to hypolipidemic fibrates that act as activators of the peroxisome proliferator-activated receptor-α, a regulator of bile acid synthesis, metabolism and transport. The present study aimed at evaluating the effects of fenofibrate on the circulating bile acid profile in humans. Hundred healthy men and women completed a 3-week intervention with fenofibrate, and 17 bile acid species were measured in serum samples drawn before and after fenofibrate treatment. Fenofibrate caused significant reductions in levels of chenodeoxycholic (−26.4%), ursodeoxycholic (−30.5%), lithocholic (−18.4%), deoxycholic (−22.3%) and hyodeoxycholic (−19.2%) acids. A gender-related difference was observed in the response of various bile acids and the total bile acid concentration was significantly reduced only in men (−18.6%), while remaining almost unchanged in women (+0.36%). This difference detected suggests that fenofibrate should be more efficient at reducing bile acid toxicity in men than in women in cholestatic liver diseases. 2011-06-29 2011-08 /pmc/articles/PMC4666518/ /pubmed/21716269 http://dx.doi.org/10.1038/clpt.2011.124 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Trottier, J. Caron, P. Straka, R. J. Barbier, O. Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate |
title | Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate |
title_full | Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate |
title_fullStr | Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate |
title_full_unstemmed | Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate |
title_short | Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate |
title_sort | profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666518/ https://www.ncbi.nlm.nih.gov/pubmed/21716269 http://dx.doi.org/10.1038/clpt.2011.124 |
work_keys_str_mv | AT trottierj profileofserumbileacidsinnoncholestaticvolunteersgenderrelateddifferencesinresponsetofenofibrate AT caronp profileofserumbileacidsinnoncholestaticvolunteersgenderrelateddifferencesinresponsetofenofibrate AT strakarj profileofserumbileacidsinnoncholestaticvolunteersgenderrelateddifferencesinresponsetofenofibrate AT barbiero profileofserumbileacidsinnoncholestaticvolunteersgenderrelateddifferencesinresponsetofenofibrate |