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Burden of laboratory-confirmed Campylobacter infections in Guatemala 2008–2012: Results from a facility-based surveillance system
Introduction: Campylobacteriosis is one of the leading causes of gastroenteritis worldwide. This study describes the epidemiology of laboratory-confirmed Campylobacter diarrheal infections in two facility-based surveillance sites in Guatemala. Methods: Clinical, epidemiologic, and laboratory data we...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Atlantis Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666523/ https://www.ncbi.nlm.nih.gov/pubmed/24534336 http://dx.doi.org/10.1016/j.jegh.2013.10.001 |
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author | Benoit, Stephen R. Lopez, Beatriz Arvelo, Wences Henao, Olga Parsons, Michele B. Reyes, Lissette Moir, Juan Carlos Lindblade, Kim |
author_facet | Benoit, Stephen R. Lopez, Beatriz Arvelo, Wences Henao, Olga Parsons, Michele B. Reyes, Lissette Moir, Juan Carlos Lindblade, Kim |
author_sort | Benoit, Stephen R. |
collection | PubMed |
description | Introduction: Campylobacteriosis is one of the leading causes of gastroenteritis worldwide. This study describes the epidemiology of laboratory-confirmed Campylobacter diarrheal infections in two facility-based surveillance sites in Guatemala. Methods: Clinical, epidemiologic, and laboratory data were collected on patients presenting with acute diarrhea from select healthcare facilities in the departments of Santa Rosa and Quetzaltenango, Guatemala, from January 2008 through August 2012. Stool specimens were cultured for Campylobacter and antimicrobial susceptibility testing was performed on a subset of isolates. Multidrug resistance (MDR) was defined as resistance to ⩾3 antimicrobial classes. Results: Campylobacter was isolated from 306 (6.0%) of 5137 stool specimens collected. For children <5 years of age, annual incidence was as high as 1288.8 per 100,000 children in Santa Rosa and 185.5 per 100,000 children in Quetzaltenango. Among 224 ambulatory care patients with Campylobacter, 169 (75.5%) received metronidazole or trimethoprim-sulfamethoxazole, and 152 (66.7%) received or were prescribed oral rehydration therapy. Antimicrobial susceptibilities were tested in 96 isolates; 57 (59.4%) were resistant to ciprofloxacin and 12 (12.5%) were MDR. Conclusion: Campylobacter was a major cause of diarrhea in children in two departments in Guatemala; antimicrobial resistance was high, and treatment regimens in the ambulatory setting which included metronidazole and trimethoprim-sulfamethoxazole and lacked oral rehydration were sub-optimal. |
format | Online Article Text |
id | pubmed-4666523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Atlantis Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46665232015-12-01 Burden of laboratory-confirmed Campylobacter infections in Guatemala 2008–2012: Results from a facility-based surveillance system Benoit, Stephen R. Lopez, Beatriz Arvelo, Wences Henao, Olga Parsons, Michele B. Reyes, Lissette Moir, Juan Carlos Lindblade, Kim J Epidemiol Glob Health Article Introduction: Campylobacteriosis is one of the leading causes of gastroenteritis worldwide. This study describes the epidemiology of laboratory-confirmed Campylobacter diarrheal infections in two facility-based surveillance sites in Guatemala. Methods: Clinical, epidemiologic, and laboratory data were collected on patients presenting with acute diarrhea from select healthcare facilities in the departments of Santa Rosa and Quetzaltenango, Guatemala, from January 2008 through August 2012. Stool specimens were cultured for Campylobacter and antimicrobial susceptibility testing was performed on a subset of isolates. Multidrug resistance (MDR) was defined as resistance to ⩾3 antimicrobial classes. Results: Campylobacter was isolated from 306 (6.0%) of 5137 stool specimens collected. For children <5 years of age, annual incidence was as high as 1288.8 per 100,000 children in Santa Rosa and 185.5 per 100,000 children in Quetzaltenango. Among 224 ambulatory care patients with Campylobacter, 169 (75.5%) received metronidazole or trimethoprim-sulfamethoxazole, and 152 (66.7%) received or were prescribed oral rehydration therapy. Antimicrobial susceptibilities were tested in 96 isolates; 57 (59.4%) were resistant to ciprofloxacin and 12 (12.5%) were MDR. Conclusion: Campylobacter was a major cause of diarrhea in children in two departments in Guatemala; antimicrobial resistance was high, and treatment regimens in the ambulatory setting which included metronidazole and trimethoprim-sulfamethoxazole and lacked oral rehydration were sub-optimal. Atlantis Press 2014 2013-11-12 /pmc/articles/PMC4666523/ /pubmed/24534336 http://dx.doi.org/10.1016/j.jegh.2013.10.001 Text en Published by Elsevier Ltd. on behalf of Ministry of Health, Saudi Arabia. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Benoit, Stephen R. Lopez, Beatriz Arvelo, Wences Henao, Olga Parsons, Michele B. Reyes, Lissette Moir, Juan Carlos Lindblade, Kim Burden of laboratory-confirmed Campylobacter infections in Guatemala 2008–2012: Results from a facility-based surveillance system |
title | Burden of laboratory-confirmed Campylobacter infections in Guatemala 2008–2012: Results from a facility-based surveillance system |
title_full | Burden of laboratory-confirmed Campylobacter infections in Guatemala 2008–2012: Results from a facility-based surveillance system |
title_fullStr | Burden of laboratory-confirmed Campylobacter infections in Guatemala 2008–2012: Results from a facility-based surveillance system |
title_full_unstemmed | Burden of laboratory-confirmed Campylobacter infections in Guatemala 2008–2012: Results from a facility-based surveillance system |
title_short | Burden of laboratory-confirmed Campylobacter infections in Guatemala 2008–2012: Results from a facility-based surveillance system |
title_sort | burden of laboratory-confirmed campylobacter infections in guatemala 2008–2012: results from a facility-based surveillance system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666523/ https://www.ncbi.nlm.nih.gov/pubmed/24534336 http://dx.doi.org/10.1016/j.jegh.2013.10.001 |
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