Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome

Transposable elements (TEs) have been active in the mammalian genome for millions of years and the silencing of these elements in the germline is important for the survival of the host. Mice carrying reporter transgenes can be used to model transcriptional silencing. A mutagenesis screen for modifie...

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Detalles Bibliográficos
Autores principales: Isbel, Luke, Srivastava, Rahul, Oey, Harald, Spurling, Alex, Daxinger, Lucia, Puthalakath, Hamsa, Whitelaw, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666613/
https://www.ncbi.nlm.nih.gov/pubmed/26624618
http://dx.doi.org/10.1371/journal.pgen.1005693

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