Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis

D76N is the first natural variant of human β-2 microglobulin (β2m) so far identified. Contrary to the wt protein, this mutant readily forms amyloid fibres in physiological conditions, leading to a systemic and severe amyloidosis. Although the Asp76Asn mutant has been extensively characterized, the m...

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Detalles Bibliográficos
Autores principales: de Rosa, Matteo, Barbiroli, Alberto, Giorgetti, Sofia, Mangione, Patrizia P., Bolognesi, Martino, Ricagno, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666650/
https://www.ncbi.nlm.nih.gov/pubmed/26625273
http://dx.doi.org/10.1371/journal.pone.0144061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666650/
https://www.ncbi.nlm.nih.gov/pubmed/26625273
http://dx.doi.org/10.1371/journal.pone.0144061

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