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orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins

Finding homologous and orthologous protein sequences is often the first step in evolutionary studies, annotation projects, and experiments of functional complementation. Despite all currently available computational tools, there is a requirement for easy-to-use tools that provide functional informat...

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Detalles Bibliográficos
Autores principales: Mier, Pablo, Andrade-Navarro, Miguel A., Pérez-Pulido, Antonio J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666658/
https://www.ncbi.nlm.nih.gov/pubmed/26624019
http://dx.doi.org/10.1371/journal.pone.0143906
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author Mier, Pablo
Andrade-Navarro, Miguel A.
Pérez-Pulido, Antonio J.
author_facet Mier, Pablo
Andrade-Navarro, Miguel A.
Pérez-Pulido, Antonio J.
author_sort Mier, Pablo
collection PubMed
description Finding homologous and orthologous protein sequences is often the first step in evolutionary studies, annotation projects, and experiments of functional complementation. Despite all currently available computational tools, there is a requirement for easy-to-use tools that provide functional information. Here, a new web application called orthoFind is presented, which allows a quick search for homologous and orthologous proteins given one or more query sequences, allowing a recurrent and exhaustive search against reference proteomes, and being able to include user databases. It addresses the protein multidomain problem, searching for homologs with the same domain architecture, and gives a simple functional analysis of the results to help in the annotation process. orthoFind is easy to use and has been proven to provide accurate results with different datasets. Availability: http://www.bioinfocabd.upo.es/orthofind/.
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spelling pubmed-46666582015-12-10 orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins Mier, Pablo Andrade-Navarro, Miguel A. Pérez-Pulido, Antonio J. PLoS One Research Article Finding homologous and orthologous protein sequences is often the first step in evolutionary studies, annotation projects, and experiments of functional complementation. Despite all currently available computational tools, there is a requirement for easy-to-use tools that provide functional information. Here, a new web application called orthoFind is presented, which allows a quick search for homologous and orthologous proteins given one or more query sequences, allowing a recurrent and exhaustive search against reference proteomes, and being able to include user databases. It addresses the protein multidomain problem, searching for homologs with the same domain architecture, and gives a simple functional analysis of the results to help in the annotation process. orthoFind is easy to use and has been proven to provide accurate results with different datasets. Availability: http://www.bioinfocabd.upo.es/orthofind/. Public Library of Science 2015-12-01 /pmc/articles/PMC4666658/ /pubmed/26624019 http://dx.doi.org/10.1371/journal.pone.0143906 Text en © 2015 Mier et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mier, Pablo
Andrade-Navarro, Miguel A.
Pérez-Pulido, Antonio J.
orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins
title orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins
title_full orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins
title_fullStr orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins
title_full_unstemmed orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins
title_short orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins
title_sort orthofind facilitates the discovery of homologous and orthologous proteins
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666658/
https://www.ncbi.nlm.nih.gov/pubmed/26624019
http://dx.doi.org/10.1371/journal.pone.0143906
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