Cargando…

Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion

BACKGROUND: The trigeminal ganglion (TG) plays a central role in cranial pain. Administration of complete Freund’s adjuvant (CFA) into the temporomandibular joint (TMJ) elicits activation of TG. Kynurenic acid (KYNA) is an endogenous excitatory amino acid receptor blocker, which may have an anti-inf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Csáti, A., Edvinsson, L., Vécsei, L., Toldi, J., Fülöp, F., Tajti, J., Warfvinge, K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Milan 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666855/ https://www.ncbi.nlm.nih.gov/pubmed/26627709 http://dx.doi.org/10.1186/s10194-015-0581-x

Ejemplares similares

KYNA analogue SZR72 modifies CFA-induced dural inflammation- regarding expression of pERK1/2 and IL-1β in the rat trigeminal ganglion
por: Lukács, M., et al.
Publicado: (2016)

Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)
por: Lukács, M., et al.
Publicado: (2017)

Dural administration of inflammatory soup or Complete Freund’s Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion
por: Lukács, M., et al.
Publicado: (2015)

Modulation of inflammatory mediators in the trigeminal ganglion by botulinum neurotoxin type A: an organ culture study
por: Edvinsson, Jacob, et al.
Publicado: (2015)

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects
por: Majláth, Zsófia, et al.
Publicado: (2016)

Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion
por: Edvinsson, Lars, et al.
Publicado: (2020)

Structural Evaluation and Electrophysiological Effects of Some Kynurenic Acid Analogs
por: Fehér, Evelin, et al.
Publicado: (2019)

Kynurenic Acid Inhibits the Electrical Stimulation Induced Elevated Pituitary Adenylate Cyclase-Activating Polypeptide Expression in the TNC
por: Körtési, Tamás, et al.
Publicado: (2018)

Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood–brain barrier permeability
por: Oláh, Gáspár, et al.
Publicado: (2013)

Neurogenic inflammation: a study of rat trigeminal ganglion
por: Kristiansen, Kim Anker, et al.
Publicado: (2010)

Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues
por: Knapp, Levente, et al.
Publicado: (2016)

Cuprizone markedly decreases kynurenic acid levels in the rodent brain tissue and plasma
por: Polyák, Helga, et al.
Publicado: (2021)

Treatment of Chronic Migraine with OnabotulinumtoxinA: Mode of Action, Efficacy and Safety
por: Szok, Délia, et al.
Publicado: (2015)

Chronic Migraine as a Primary Chronic Pain Syndrome and Recommended Prophylactic Therapeutic Options: A Literature Review
por: Szok, Délia, et al.
Publicado: (2023)

Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers
por: Datki, Zsolt, et al.
Publicado: (2019)

Kynurenic Acid Analog Attenuates the Production of Tumor Necrosis Factor-α, Calgranulins (S100A 8/9 and S100A 12), and the Secretion of HNP1–3 and Stimulates the Production of Tumor Necrosis Factor-Stimulated Gene-6 in Whole Blood Cultures of Patients With Rheumatoid Arthritis
por: Balog, Attila, et al.
Publicado: (2021)

The Opposite Effects of Kynurenic Acid and Different Kynurenic Acid Analogs on Tumor Necrosis Factor-α (TNF-α) Production and Tumor Necrosis Factor-Stimulated Gene-6 (TSG-6) Expression
por: Mándi, Yvette, et al.
Publicado: (2019)

Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid
por: Tóth, Fanni, et al.
Publicado: (2021)

Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission
por: Martos, Diána, et al.
Publicado: (2022)

Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex
por: Maddahi, Aida, et al.
Publicado: (2022)

Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex
por: Maddahi, Aida, et al.
Publicado: (2023)

Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid
por: Spekker, Eleonóra, et al.
Publicado: (2021)

Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation Is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104
por: Lajkó, Noémi, et al.
Publicado: (2020)

Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice
por: Nahomi, Rooban B., et al.
Publicado: (2020)

Sensory nerves in the human cerebral circulation and trigeminal ganglion: role in primary headaches
por: Edvinsson, Lars
Publicado: (2002)

Kynurenic Acid and Its Analogue SZR-72 Ameliorate the Severity of Experimental Acute Necrotizing Pancreatitis
por: Balla, Zsolt, et al.
Publicado: (2021)

Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain
por: Tajti, János, et al.
Publicado: (2023)

Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain
por: Edvinsson, Jacob CA, et al.
Publicado: (2021)

SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier
por: Molnár, Kinga, et al.
Publicado: (2021)

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives
por: Lőrinczi, Bálint, et al.
Publicado: (2020)

Divergent Effects of the N-Methyl-D-Aspartate Receptor Antagonist Kynurenic Acid and the Synthetic Analog SZR-72 on Microcirculatory and Mitochondrial Dysfunction in Experimental Sepsis
por: Juhász, László, et al.
Publicado: (2020)

C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system
por: Edvinsson, Jacob C. A., et al.
Publicado: (2019)

Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects
por: Warfvinge, Karin, et al.
Publicado: (2020)

PACAP and its role in primary headaches
por: Edvinsson, Lars, et al.
Publicado: (2018)

Expression of messenger molecules and receptors in rat and human sphenopalatine ganglion indicating therapeutic targets
por: Steinberg, Anna, et al.
Publicado: (2016)

Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats
por: Poles, Marietta Z., et al.
Publicado: (2021)

Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT(1) receptors
por: Edvinsson, Jacob C. A., et al.
Publicado: (2022)

The kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia
por: Szabo, Melinda, et al.
Publicado: (2023)

Erratum to: Expression of messenger molecules and receptors in rat and human sphenopalatine ganglion indicating therapeutic targets
por: Steinberg, Anna, et al.
Publicado: (2016)

Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations
por: Bohár, Zsuzsanna, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ovvq73gp1oh1o8h2j5bgik5la4