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Principles of the prolactin/vasoinhibin axis
The hormonal family of vasoinhibins, which derive from the anterior pituitary hormone prolactin, are known for their inhibiting effects on blood vessel growth, vasopermeability, and vasodilation. As pleiotropic hormones, vasoinhibins act in multiple target organs and tissues. The generation, secreti...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Physiological Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666935/ https://www.ncbi.nlm.nih.gov/pubmed/26310939 http://dx.doi.org/10.1152/ajpregu.00256.2015 |
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author | Triebel, Jakob Bertsch, Thomas Bollheimer, Cornelius Rios-Barrera, Daniel Pearce, Christy F. Hüfner, Michael Martínez de la Escalera, Gonzalo Clapp, Carmen |
author_facet | Triebel, Jakob Bertsch, Thomas Bollheimer, Cornelius Rios-Barrera, Daniel Pearce, Christy F. Hüfner, Michael Martínez de la Escalera, Gonzalo Clapp, Carmen |
author_sort | Triebel, Jakob |
collection | PubMed |
description | The hormonal family of vasoinhibins, which derive from the anterior pituitary hormone prolactin, are known for their inhibiting effects on blood vessel growth, vasopermeability, and vasodilation. As pleiotropic hormones, vasoinhibins act in multiple target organs and tissues. The generation, secretion, and regulation of vasoinhibins are embedded into the organizational principle of an axis, which integrates the hypothalamus, the pituitary, and the target tissue microenvironment. This axis is designated as the prolactin/vasoinhibin axis. Disturbances of the prolactin/vasoinhibin axis are associated with the pathogenesis of retinal and cardiac diseases and with diseases occurring during pregnancy. New phylogenetical, physiological, and clinical implications are discussed. |
format | Online Article Text |
id | pubmed-4666935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | American Physiological Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-46669352015-12-07 Principles of the prolactin/vasoinhibin axis Triebel, Jakob Bertsch, Thomas Bollheimer, Cornelius Rios-Barrera, Daniel Pearce, Christy F. Hüfner, Michael Martínez de la Escalera, Gonzalo Clapp, Carmen Am J Physiol Regul Integr Comp Physiol Review The hormonal family of vasoinhibins, which derive from the anterior pituitary hormone prolactin, are known for their inhibiting effects on blood vessel growth, vasopermeability, and vasodilation. As pleiotropic hormones, vasoinhibins act in multiple target organs and tissues. The generation, secretion, and regulation of vasoinhibins are embedded into the organizational principle of an axis, which integrates the hypothalamus, the pituitary, and the target tissue microenvironment. This axis is designated as the prolactin/vasoinhibin axis. Disturbances of the prolactin/vasoinhibin axis are associated with the pathogenesis of retinal and cardiac diseases and with diseases occurring during pregnancy. New phylogenetical, physiological, and clinical implications are discussed. American Physiological Society 2015-08-26 2015-11-15 /pmc/articles/PMC4666935/ /pubmed/26310939 http://dx.doi.org/10.1152/ajpregu.00256.2015 Text en Copyright © 2015 the American Physiological Society http://creativecommons.org/licenses/by/3.0/deed.en_US Licensed under Creative Commons Attribution CC-BY 3.0 (http://creativecommons.org/licenses/by/3.0/deed.en_US) : © the American Physiological Society. |
spellingShingle | Review Triebel, Jakob Bertsch, Thomas Bollheimer, Cornelius Rios-Barrera, Daniel Pearce, Christy F. Hüfner, Michael Martínez de la Escalera, Gonzalo Clapp, Carmen Principles of the prolactin/vasoinhibin axis |
title | Principles of the prolactin/vasoinhibin axis |
title_full | Principles of the prolactin/vasoinhibin axis |
title_fullStr | Principles of the prolactin/vasoinhibin axis |
title_full_unstemmed | Principles of the prolactin/vasoinhibin axis |
title_short | Principles of the prolactin/vasoinhibin axis |
title_sort | principles of the prolactin/vasoinhibin axis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666935/ https://www.ncbi.nlm.nih.gov/pubmed/26310939 http://dx.doi.org/10.1152/ajpregu.00256.2015 |
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