Cargando…

The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome

Ang II type 1a receptor (AT(1a)R)-mediated activation of MAPKs contributes to thoracic aortic aneurysm (TAA) development in Marfan syndrome (MFS). β-Arrestin2 (βarr2) is known to mediate AT(1a)R-dependent MAPK activation, as well as proproliferative and profibrotic signaling in aortic vascular smoot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wisler, James W., Harris, Emily M., Raisch, Michael, Mao, Lan, Kim, Jihee, Rockman, Howard A., Lefkowitz, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Physiological Society 2015
Materias:	Signaling and Stress Response
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666970/ https://www.ncbi.nlm.nih.gov/pubmed/26371162 http://dx.doi.org/10.1152/ajpheart.00291.2015

Ejemplares similares

Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury
por: Egom, Emmanuel Eroume A., et al.
Publicado: (2011)

Circulating micrornas as potential biomarkers of aerobic exercise capacity
por: Mooren, Frank C., et al.
Publicado: (2013)

β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
por: Ahn, Seungkirl, et al.
Publicado: (2009)

Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4
por: Shukla, Arun K., et al.
Publicado: (2010)

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
por: Kim, Jihee, et al.
Publicado: (2018)

Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions
por: Torrent, Marc, et al.
Publicado: (2018)

Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes
por: Pakharukova, Natalia, et al.
Publicado: (2021)

Independent β-Arrestin2 and G(q)/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor
por: Kim, Jihee, et al.
Publicado: (2009)

AVR2 Targets BSL Family Members, Which Act as Susceptibility Factors to Suppress Host Immunity
por: Turnbull, Dionne, et al.
Publicado: (2019)

Pathophysiology and Therapeutics of Thoracic Aortic Aneurysm in Marfan Syndrome
por: Asano, Keiichi, et al.
Publicado: (2022)

Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms
por: Gomez, Delphine, et al.
Publicado: (2011)

β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19
por: Manglik, Aashish, et al.
Publicado: (2020)

Temporal Profiling of Orexin Receptor-Arrestin-Ubiquitin Complexes Reveals Differences between Receptor Subtypes
por: Dalrymple, Matthew B., et al.
Publicado: (2011)

Thoracic Aortic Aneurysm Surgery in Marfan Patients: a Perspective from the UK
por: Harky, Amer, et al.
Publicado: (2020)

Concomitant Action of Structural Elements and Receptor Phosphorylation Determines Arrestin-3 Interaction with the Free Fatty Acid Receptor FFA4
por: Butcher, Adrian J., et al.
Publicado: (2014)

Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling
por: Alvarez-Curto, Elisa, et al.
Publicado: (2016)

G Protein–Coupled Receptor Kinase 2, With β-Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling in ob/ob Mouse Aorta
por: Taguchi, Kumiko, et al.
Publicado: (2012)

Scutellarin attenuates hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and oxidative stress through regulating Keap1/Nrf2/ARE signaling
por: Wu, Haiyuan, et al.
Publicado: (2019)

Marfan Syndrome - Acute Aortic Dissection Due to Giant Aortic Aneurysm
por: MUNTEANU, O., et al.
Publicado: (2017)

Treatment experience of thoracic aortic aneurysm recurrence after multiple surgeries for Marfan syndrome: A case report
por: Chen, Huai-Dong, et al.
Publicado: (2019)

A novel variant in fibrillin-1 is responsible for early-onset familial thoracic aortic aneurysms in Marfan patients
por: Duan, Yanyu, et al.
Publicado: (2021)

Participation of Arachidonic Acid Metabolism in the Aortic Aneurysm Formation in Patients with Marfan Syndrome
por: Soto, María E., et al.
Publicado: (2018)

Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC)
por: Roman, Mary J., et al.
Publicado: (2016)

Androgens Accentuate TGF‐β Dependent Erk/Smad Activation During Thoracic Aortic Aneurysm Formation in Marfan Syndrome Male Mice
por: Tashima, Yasushi, et al.
Publicado: (2020)

The revised role of TGF-β in aortic aneurysms in Marfan syndrome
por: Franken, R., et al.
Publicado: (2014)

Cyclophilin A/EMMPRIN Axis Is Involved in Pro-Fibrotic Processes Associated with Thoracic Aortic Aneurysm of Marfan Syndrome Patients
por: Perrucci, Gianluca L., et al.
Publicado: (2020)

Differences in the Thoracic Aorta by Region and Sex in a Murine Model of Marfan Syndrome
por: Jiménez-Altayó, Francesc, et al.
Publicado: (2017)

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle
por: Nieto-Vazquez, Iria, et al.
Publicado: (2008)

Thoracic Aortic Aneurysms
por: Duckworth, Dyce
Publicado: (1908)

Medical Treatment of Aortic Aneurysms in Marfan Syndrome and other Heritable Conditions
por: Jost, Christine H. Attenhofer, et al.
Publicado: (2014)

Ruptured abdominal aortic aneurysm repair in pediatric Marfan syndrome patient
por: Lu, Joyce J., et al.
Publicado: (2018)

Impact of Notch3 Activation on Aortic Aneurysm Development in Marfan Syndrome
por: Jespersen, Kathryn, et al.
Publicado: (2022)

TGFB2 loss of function mutations cause familial thoracic aortic aneurysms and acute aortic dissections associated with mild systemic features of the Marfan syndrome
por: Boileau, Catherine, et al.
Publicado: (2012)

ERK Signals: Scaffolding Scaffolds?
por: Casar, Berta, et al.
Publicado: (2016)

Culturing primary neurons from rat hippocampus and cortex
por: Sahu, Madhusmita Priyadarshini, et al.
Publicado: (2019)

Cotinine inhibits TLR4/NF-κB signaling pathway and improves deep vein thrombosis in rats
por: Cheng, Zhiyuan, et al.
Publicado: (2020)

miR-26a-5p mediates TLR signaling pathway by targeting CTGF in LPS-induced alveolar macrophage
por: Li, Chunyan, et al.
Publicado: (2020)

Non-coding RNAs in neuropathic pain
por: Kalpachidou, Theodora, et al.
Publicado: (2020)

Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane
por: Katan, Matilda, et al.
Publicado: (2020)

TRIM31 promotes acute myeloid leukemia progression and sensitivity to daunorubicin through the Wnt/β-catenin signaling
por: Xiao, Yi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_43vt4edbu3mgj8jg4eu0ifmphj