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Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825)
Tropidurus hispidus has been used in traditional medicine in several regions of Northeastern Region of Brazil. Its medicinal use involves the treatment of diseases such as warts, sore throat, tonsillitis, chicken pox, varicella, measles, asthma, alcoholism, and dermatomycosis. The present study eval...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667054/ https://www.ncbi.nlm.nih.gov/pubmed/26664448 http://dx.doi.org/10.1155/2015/140247 |
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author | Santos, Israel J. M. Leite, Gerlânia O. Costa, José Galberto M. Alves, Romulo R. N. Campos, Adriana R. Menezes, Irwin R. A. Freita, Francisco Ronaldo V. Nunes, Maria Janeth H. Almeida, Waltécio O. |
author_facet | Santos, Israel J. M. Leite, Gerlânia O. Costa, José Galberto M. Alves, Romulo R. N. Campos, Adriana R. Menezes, Irwin R. A. Freita, Francisco Ronaldo V. Nunes, Maria Janeth H. Almeida, Waltécio O. |
author_sort | Santos, Israel J. M. |
collection | PubMed |
description | Tropidurus hispidus has been used in traditional medicine in several regions of Northeastern Region of Brazil. Its medicinal use involves the treatment of diseases such as warts, sore throat, tonsillitis, chicken pox, varicella, measles, asthma, alcoholism, and dermatomycosis. The present study evaluated the topical anti-inflammatory activity of Tropidurus hispidus fat in treating ear edema in an animal model. Oil from T. hispidus (OTH) was evaluated on its effect against experimental inflammation in mice. OTH was extracted from body fat located in the ventral region of Tropidurus hispidus using hexane as a solvent. We used the model of mouse ear edema induced by phlogistic agents, croton oil (single and multiple applications), arachidonic acid, phenol, capsaicin, and histamine, applied into the right ears of animals pretreated with acetone (control), dexamethasone, or OTH. OTH inhibited the dermatitis induced by all noxious agents, except capsaicin. This effect may be related to the fatty acids present in OTH. |
format | Online Article Text |
id | pubmed-4667054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46670542015-12-09 Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825) Santos, Israel J. M. Leite, Gerlânia O. Costa, José Galberto M. Alves, Romulo R. N. Campos, Adriana R. Menezes, Irwin R. A. Freita, Francisco Ronaldo V. Nunes, Maria Janeth H. Almeida, Waltécio O. Evid Based Complement Alternat Med Research Article Tropidurus hispidus has been used in traditional medicine in several regions of Northeastern Region of Brazil. Its medicinal use involves the treatment of diseases such as warts, sore throat, tonsillitis, chicken pox, varicella, measles, asthma, alcoholism, and dermatomycosis. The present study evaluated the topical anti-inflammatory activity of Tropidurus hispidus fat in treating ear edema in an animal model. Oil from T. hispidus (OTH) was evaluated on its effect against experimental inflammation in mice. OTH was extracted from body fat located in the ventral region of Tropidurus hispidus using hexane as a solvent. We used the model of mouse ear edema induced by phlogistic agents, croton oil (single and multiple applications), arachidonic acid, phenol, capsaicin, and histamine, applied into the right ears of animals pretreated with acetone (control), dexamethasone, or OTH. OTH inhibited the dermatitis induced by all noxious agents, except capsaicin. This effect may be related to the fatty acids present in OTH. Hindawi Publishing Corporation 2015 2015-11-18 /pmc/articles/PMC4667054/ /pubmed/26664448 http://dx.doi.org/10.1155/2015/140247 Text en Copyright © 2015 Israel J. M. Santos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Santos, Israel J. M. Leite, Gerlânia O. Costa, José Galberto M. Alves, Romulo R. N. Campos, Adriana R. Menezes, Irwin R. A. Freita, Francisco Ronaldo V. Nunes, Maria Janeth H. Almeida, Waltécio O. Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825) |
title | Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825) |
title_full | Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825) |
title_fullStr | Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825) |
title_full_unstemmed | Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825) |
title_short | Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825) |
title_sort | topical anti-inflammatory activity of oil from tropidurus hispidus (spix, 1825) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667054/ https://www.ncbi.nlm.nih.gov/pubmed/26664448 http://dx.doi.org/10.1155/2015/140247 |
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