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Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin G response to 14 pathogenic viruses in 2,363 immunocompetent adults. Significant associ...

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Detalles Bibliográficos
Autores principales:	Hammer, Christian, Begemann, Martin, McLaren, Paul J., Bartha, István, Michel, Angelika, Klose, Beate, Schmitt, Corinna, Waterboer, Tim, Pawlita, Michael, Schulz, Thomas F., Ehrenreich, Hannelore, Fellay, Jacques
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667104/ https://www.ncbi.nlm.nih.gov/pubmed/26456283 http://dx.doi.org/10.1016/j.ajhg.2015.09.008

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