M(1) and M(3) muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product

The smoke of crack cocaine contains cocaine and its pyrolysis product, anhydroecgonine methyl ester (AEME). AEME possesses greater neurotoxic potential than cocaine and an additive effect when they are combined. Since atropine prevented AEME-induced neurotoxicity, it has been suggested that its toxi...

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Detalles Bibliográficos
Autores principales: Garcia, Raphael Caio Tamborelli, Dati, Livia Mendonça Munhoz, Torres, Larissa Helena, da Silva, Mariana Aguilera Alencar, Udo, Mariana Sayuri Berto, Abdalla, Fernando Maurício Francis, da Costa, José Luiz, Gorjão, Renata, Afeche, Solange Castro, Yonamine, Mauricio, Niswender, Colleen M., Conn, P. Jeffrey, Camarini, Rosana, Sandoval, Maria Regina Lopes, Marcourakis, Tania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667193/
https://www.ncbi.nlm.nih.gov/pubmed/26626425
http://dx.doi.org/10.1038/srep17555

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