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Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. Therefore, novel therapeutic targets for protecting the heart against acute ischemia/reperfusion injury (IRI) are required to attenuate cardiomyocyte death, preserve myocardial function, and prevent the onset of hea...

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Autores principales: Mukherjee, Uma A., Ong, Sang-Bing, Ong, Sang-Ging, Hausenloy, Derek J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667215/
https://www.ncbi.nlm.nih.gov/pubmed/26481155
http://dx.doi.org/10.1016/j.pharmthera.2015.10.005
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author Mukherjee, Uma A.
Ong, Sang-Bing
Ong, Sang-Ging
Hausenloy, Derek J.
author_facet Mukherjee, Uma A.
Ong, Sang-Bing
Ong, Sang-Ging
Hausenloy, Derek J.
author_sort Mukherjee, Uma A.
collection PubMed
description Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. Therefore, novel therapeutic targets for protecting the heart against acute ischemia/reperfusion injury (IRI) are required to attenuate cardiomyocyte death, preserve myocardial function, and prevent the onset of heart failure. In this regard, a specific group of mitochondrial proteins, which have been linked to familial forms of Parkinson's disease (PD), may provide novel therapeutic targets for cardioprotection. In dopaminergic neurons of the substantia nigra, these PD proteins, which include Parkin, PINK1, DJ-1, LRRK2, and α-synuclein, play essential roles in preventing cell death—through maintaining normal mitochondrial function, protecting against oxidative stress, mediating mitophagy, and preventing apoptosis. These rare familial forms of PD may therefore provide important insights into the pathophysiology underlying mitochondrial dysfunction and the development of PD. Interestingly, these PD proteins are also present in the heart, but their role in myocardial health and disease is not clear. In this article, we review the role of these PD proteins in the heart and explore their potential as novel mitochondrial targets for cardioprotection.
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spelling pubmed-46672152015-12-22 Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection Mukherjee, Uma A. Ong, Sang-Bing Ong, Sang-Ging Hausenloy, Derek J. Pharmacol Ther Article Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. Therefore, novel therapeutic targets for protecting the heart against acute ischemia/reperfusion injury (IRI) are required to attenuate cardiomyocyte death, preserve myocardial function, and prevent the onset of heart failure. In this regard, a specific group of mitochondrial proteins, which have been linked to familial forms of Parkinson's disease (PD), may provide novel therapeutic targets for cardioprotection. In dopaminergic neurons of the substantia nigra, these PD proteins, which include Parkin, PINK1, DJ-1, LRRK2, and α-synuclein, play essential roles in preventing cell death—through maintaining normal mitochondrial function, protecting against oxidative stress, mediating mitophagy, and preventing apoptosis. These rare familial forms of PD may therefore provide important insights into the pathophysiology underlying mitochondrial dysfunction and the development of PD. Interestingly, these PD proteins are also present in the heart, but their role in myocardial health and disease is not clear. In this article, we review the role of these PD proteins in the heart and explore their potential as novel mitochondrial targets for cardioprotection. Pergamon Press 2015-12 /pmc/articles/PMC4667215/ /pubmed/26481155 http://dx.doi.org/10.1016/j.pharmthera.2015.10.005 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mukherjee, Uma A.
Ong, Sang-Bing
Ong, Sang-Ging
Hausenloy, Derek J.
Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection
title Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection
title_full Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection
title_fullStr Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection
title_full_unstemmed Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection
title_short Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection
title_sort parkinson's disease proteins: novel mitochondrial targets for cardioprotection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667215/
https://www.ncbi.nlm.nih.gov/pubmed/26481155
http://dx.doi.org/10.1016/j.pharmthera.2015.10.005
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