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Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2

Shp2 is a ubiquitously expressed protein tyrosine phosphatase (PTP) related to adult acute myelogenous leukemia and human solid tumors. In this report, we describe identification of a potent Shp2 inhibitor, Fumosorinone (Fumos) from entomogenous fungi, which shows selective inhibition of Shp2 over o...

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Detalles Bibliográficos
Autores principales:	Chen, Chuan, Cao, Mengmeng, Zhu, Siyu, Wang, Cuicui, Liang, Fan, Yan, Leilei, Luo, Duqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667271/ https://www.ncbi.nlm.nih.gov/pubmed/26626996 http://dx.doi.org/10.1038/srep17626

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