SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes

Expression of the p53-inducible antiproliferative gene BTG2 is suppressed in many cancers in the absence of inactivating gene mutations, suggesting alternative mechanisms of silencing. Using a shRNA screen targeting 43 histone lysine methyltransferases (KMTs), we show that SETD1A suppresses BTG2 exp...

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Detalles Bibliográficos
Autores principales: Tajima, Ken, Yae, Toshifumi, Javaid, Sarah, Tam, Oliver, Comaills, Valentine, Morris, Robert, Wittner, Ben S., Liu, Mingzhu, Engstrom, Amanda, Takahashi, Fumiyuki, Black, Joshua C., Ramaswamy, Sridhar, Shioda, Toshihiro, Hammell, Molly, Haber, Daniel A., Whetstine, Johnathan R., Maheswaran, Shyamala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667427/
https://www.ncbi.nlm.nih.gov/pubmed/26394836
http://dx.doi.org/10.1038/ncomms9257

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