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Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients

BACKGROUND: In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlations between the levels of sIgE to Pru p 3 with the severity of the clinical sy...

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Autores principales: Uasuf, Carina Gabriela, Villalta, Danilo, Conte, Maria Elisabetta, Di Sano, Caterina, Barrale, Maria, Cantisano, Vincenzo, Pace, Elisabetta, Gjomarkaj, Mark, Gangemi, Sebastiano, Brusca, Ignazio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667484/
https://www.ncbi.nlm.nih.gov/pubmed/26633941
http://dx.doi.org/10.1186/s12948-015-0035-7
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author Uasuf, Carina Gabriela
Villalta, Danilo
Conte, Maria Elisabetta
Di Sano, Caterina
Barrale, Maria
Cantisano, Vincenzo
Pace, Elisabetta
Gjomarkaj, Mark
Gangemi, Sebastiano
Brusca, Ignazio
author_facet Uasuf, Carina Gabriela
Villalta, Danilo
Conte, Maria Elisabetta
Di Sano, Caterina
Barrale, Maria
Cantisano, Vincenzo
Pace, Elisabetta
Gjomarkaj, Mark
Gangemi, Sebastiano
Brusca, Ignazio
author_sort Uasuf, Carina Gabriela
collection PubMed
description BACKGROUND: In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlations between the levels of sIgE to Pru p 3 with the severity of the clinical symptoms in two Pru p 3 positive populations from two different areas of Italy. METHODS: 133 consecutively Pru p 3 positive patients were recruited from South Italy, where the prevalence of PR-10 and profilin sensitization is low, and from North-East Italy, where the sensitization to pathogenesis related protein -10 (PR-10) and profilin is higher. Skin prick test (SPT) to peach extract and sIgE to peach panallergens were performed. RESULTS: All 133 patients were positive to SPT to peach extract and to sIgE to Pru p 3. The North-East population was simultaneously positive to Pru p 1 (42.8 %) and Pru p 4 (12.7 %), while no Southern patients were positive to PR-10 or to profilin. A significant difference in the levels of sIgE to Pru p 3 was found only in South Italy Pru p 3 + patients vs. asymptomatic patients (p = 0.01) and in mild reactions vs. severe reactions (p = 0.0008). In South Italy patients, it was also found a significant correlation between the severity of the clinical reaction and the levels of sIgE to Pru p 3 (p = 0.001). CONCLUSION: Level of sIgE to Pru p 3 indicates the possibility of development a severe food allergic reaction. Pru p 3 positive patients from different geographical areas and with different co-sensitizations to Pru p 1 and/or Pru p 4 could have a different risk assessment in peach allergy.
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spelling pubmed-46674842015-12-03 Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients Uasuf, Carina Gabriela Villalta, Danilo Conte, Maria Elisabetta Di Sano, Caterina Barrale, Maria Cantisano, Vincenzo Pace, Elisabetta Gjomarkaj, Mark Gangemi, Sebastiano Brusca, Ignazio Clin Mol Allergy Research BACKGROUND: In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlations between the levels of sIgE to Pru p 3 with the severity of the clinical symptoms in two Pru p 3 positive populations from two different areas of Italy. METHODS: 133 consecutively Pru p 3 positive patients were recruited from South Italy, where the prevalence of PR-10 and profilin sensitization is low, and from North-East Italy, where the sensitization to pathogenesis related protein -10 (PR-10) and profilin is higher. Skin prick test (SPT) to peach extract and sIgE to peach panallergens were performed. RESULTS: All 133 patients were positive to SPT to peach extract and to sIgE to Pru p 3. The North-East population was simultaneously positive to Pru p 1 (42.8 %) and Pru p 4 (12.7 %), while no Southern patients were positive to PR-10 or to profilin. A significant difference in the levels of sIgE to Pru p 3 was found only in South Italy Pru p 3 + patients vs. asymptomatic patients (p = 0.01) and in mild reactions vs. severe reactions (p = 0.0008). In South Italy patients, it was also found a significant correlation between the severity of the clinical reaction and the levels of sIgE to Pru p 3 (p = 0.001). CONCLUSION: Level of sIgE to Pru p 3 indicates the possibility of development a severe food allergic reaction. Pru p 3 positive patients from different geographical areas and with different co-sensitizations to Pru p 1 and/or Pru p 4 could have a different risk assessment in peach allergy. BioMed Central 2015-12-02 /pmc/articles/PMC4667484/ /pubmed/26633941 http://dx.doi.org/10.1186/s12948-015-0035-7 Text en © Uasuf et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Uasuf, Carina Gabriela
Villalta, Danilo
Conte, Maria Elisabetta
Di Sano, Caterina
Barrale, Maria
Cantisano, Vincenzo
Pace, Elisabetta
Gjomarkaj, Mark
Gangemi, Sebastiano
Brusca, Ignazio
Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients
title Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients
title_full Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients
title_fullStr Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients
title_full_unstemmed Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients
title_short Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients
title_sort different co-sensitizations could determine different risk assessment in peach allergy? evaluation of an anaphylactic biomarker in pru p 3 positive patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667484/
https://www.ncbi.nlm.nih.gov/pubmed/26633941
http://dx.doi.org/10.1186/s12948-015-0035-7
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