Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample

BACKGROUND: Presynaptic terminals contribute to cognitive reserve, balancing the effects of age-related pathologies on cognitive function in the elderly. The presynaptic protein Munc18-1, alternatively spliced into long (M18L) or short (M18S) isoforms, is a critical modulator of neurotransmission. W...

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Detalles Bibliográficos
Autores principales: Ramos-Miguel, Alfredo, Hercher, Christa, Beasley, Clare L., Barr, Alasdair M., Bayer, Thomas A., Falkai, Peter, Leurgans, Sue E., Schneider, Julie A., Bennett, David A., Honer, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667524/
https://www.ncbi.nlm.nih.gov/pubmed/26628003
http://dx.doi.org/10.1186/s13024-015-0061-4

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