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Targeting of SUMO substrates to a Cdc48–Ufd1–Npl4 segregase and STUbL pathway in fission yeast

In eukaryotes, the conjugation of proteins to the small ubiquitin-like modifier (SUMO) regulates numerous cellular functions. A proportion of SUMO conjugates are targeted for degradation by SUMO-targeted ubiquitin ligases (STUbLs) and it has been proposed that the ubiquitin-selective chaperone Cdc48...

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Detalles Bibliográficos
Autores principales: Køhler, Julie Bonne, Tammsalu, Triin, Jørgensen, Maria Mønster, Steen, Nana, Hay, Ronald Thomas, Thon, Geneviève
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667616/
https://www.ncbi.nlm.nih.gov/pubmed/26537787
http://dx.doi.org/10.1038/ncomms9827