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Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells

Patients with severe sickle cell disease (SCD) are candidates for gene therapy using autologous hematopoietic stem cells (HSCs), but concomitant multi-organ disease may contraindicate pretransplant conditioning with full myeloablation. We tested whether nonmyeloablative conditioning, a regimen used...

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Detalles Bibliográficos
Autores principales:	Pestina, Tamara I, Hargrove, Phillip W, Zhao, Huifen, Mead, Paul E, Smeltzer, Matthew P, Weiss, Mitchell J, Wilber, Andrew, Persons, Derek A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667717/ https://www.ncbi.nlm.nih.gov/pubmed/26665131 http://dx.doi.org/10.1038/mtm.2015.45

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