Cargando…

Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements

To compare anterior chamber angle parameters based on the location of Schwalbe line (SL) from 2 spectral domain optical coherence tomography (SD-OCT) instruments and to measure their reproducibility. METHODS: Forty-two eyes from 21 normal, healthy participants underwent imaging of the inferior irido...

Descripción completa

Detalles Bibliográficos
Autores principales: Marion, Kenneth M., Maram, Jyotsna, Pan, Xiaojing, Dastiridou, Anna, Zhang, ZhouYuan, Ho, Alex, Francis, Brian A., Sadda, Srinivas R., Chopra, Vikas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Raven Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667752/
https://www.ncbi.nlm.nih.gov/pubmed/26200742
http://dx.doi.org/10.1097/IJG.0000000000000303
_version_ 1782403881866625024
author Marion, Kenneth M.
Maram, Jyotsna
Pan, Xiaojing
Dastiridou, Anna
Zhang, ZhouYuan
Ho, Alex
Francis, Brian A.
Sadda, Srinivas R.
Chopra, Vikas
author_facet Marion, Kenneth M.
Maram, Jyotsna
Pan, Xiaojing
Dastiridou, Anna
Zhang, ZhouYuan
Ho, Alex
Francis, Brian A.
Sadda, Srinivas R.
Chopra, Vikas
author_sort Marion, Kenneth M.
collection PubMed
description To compare anterior chamber angle parameters based on the location of Schwalbe line (SL) from 2 spectral domain optical coherence tomography (SD-OCT) instruments and to measure their reproducibility. METHODS: Forty-two eyes from 21 normal, healthy participants underwent imaging of the inferior irido-corneal angle with the Spectralis and Cirrus SD-OCT under tightly controlled low-light conditions. SL-angle opening distance (SL-AOD) and SL-trabecular iris space area (SL-TISA) were measured by masked, certified graders at the Doheny Imaging Reading Center using customized grading software. Interinstrument and intrainstrument, as well as interobserver and intraobserver reproducibility of SL-AOD and SL-TISA measurements were evaluated by intraclass correlation coefficients (ICCs) and Bland-Altman plots with limits of agreement (LoA). RESULTS: The mean SL-AOD was 0.662±0.191 mm in Spectralis and 0.677±0.213 mm in Cirrus. The mean SL-TISA was 0.250±0.073 mm(2) in Spectralis and 0.256±0.082 mm(2) in Cirrus. The agreement for intrainstrument (ICCs>0.979), intragrader (ICCs>0.992), and intergrader (ICCs>0.929) was excellent. Excellent agreement between the 2 devices was also documented with a mean difference of −0.016 (LoA −0.125 to 0.092) mm for SL-AOD and −0.007 (LoA −0.056 to 0.043) mm(2) in SL-TISA. CONCLUSIONS: Both SD-OCTs provided comparable measurements and permitted calculation of SL-based angle metrics. There was excellent interinstrument and intrainstrument and intraobserver and interobserver reproducibility for Spectralis and Cirrus SD-OCTs, suggesting true interchangeability between SD-OCT devices. This has the potential to lead to development of standardized grading assessments and quantification of angle parameters that would be valid across various SD-OCT devices.
format Online
Article
Text
id pubmed-4667752
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Raven Press
record_format MEDLINE/PubMed
spelling pubmed-46677522015-12-09 Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements Marion, Kenneth M. Maram, Jyotsna Pan, Xiaojing Dastiridou, Anna Zhang, ZhouYuan Ho, Alex Francis, Brian A. Sadda, Srinivas R. Chopra, Vikas J Glaucoma Original Studies To compare anterior chamber angle parameters based on the location of Schwalbe line (SL) from 2 spectral domain optical coherence tomography (SD-OCT) instruments and to measure their reproducibility. METHODS: Forty-two eyes from 21 normal, healthy participants underwent imaging of the inferior irido-corneal angle with the Spectralis and Cirrus SD-OCT under tightly controlled low-light conditions. SL-angle opening distance (SL-AOD) and SL-trabecular iris space area (SL-TISA) were measured by masked, certified graders at the Doheny Imaging Reading Center using customized grading software. Interinstrument and intrainstrument, as well as interobserver and intraobserver reproducibility of SL-AOD and SL-TISA measurements were evaluated by intraclass correlation coefficients (ICCs) and Bland-Altman plots with limits of agreement (LoA). RESULTS: The mean SL-AOD was 0.662±0.191 mm in Spectralis and 0.677±0.213 mm in Cirrus. The mean SL-TISA was 0.250±0.073 mm(2) in Spectralis and 0.256±0.082 mm(2) in Cirrus. The agreement for intrainstrument (ICCs>0.979), intragrader (ICCs>0.992), and intergrader (ICCs>0.929) was excellent. Excellent agreement between the 2 devices was also documented with a mean difference of −0.016 (LoA −0.125 to 0.092) mm for SL-AOD and −0.007 (LoA −0.056 to 0.043) mm(2) in SL-TISA. CONCLUSIONS: Both SD-OCTs provided comparable measurements and permitted calculation of SL-based angle metrics. There was excellent interinstrument and intrainstrument and intraobserver and interobserver reproducibility for Spectralis and Cirrus SD-OCTs, suggesting true interchangeability between SD-OCT devices. This has the potential to lead to development of standardized grading assessments and quantification of angle parameters that would be valid across various SD-OCT devices. Raven Press 2015-12 2015-12-02 /pmc/articles/PMC4667752/ /pubmed/26200742 http://dx.doi.org/10.1097/IJG.0000000000000303 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.http://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Studies
Marion, Kenneth M.
Maram, Jyotsna
Pan, Xiaojing
Dastiridou, Anna
Zhang, ZhouYuan
Ho, Alex
Francis, Brian A.
Sadda, Srinivas R.
Chopra, Vikas
Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements
title Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements
title_full Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements
title_fullStr Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements
title_full_unstemmed Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements
title_short Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements
title_sort reproducibility and agreement between 2 spectral domain optical coherence tomography devices for anterior chamber angle measurements
topic Original Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667752/
https://www.ncbi.nlm.nih.gov/pubmed/26200742
http://dx.doi.org/10.1097/IJG.0000000000000303
work_keys_str_mv AT marionkennethm reproducibilityandagreementbetween2spectraldomainopticalcoherencetomographydevicesforanteriorchamberanglemeasurements
AT maramjyotsna reproducibilityandagreementbetween2spectraldomainopticalcoherencetomographydevicesforanteriorchamberanglemeasurements
AT panxiaojing reproducibilityandagreementbetween2spectraldomainopticalcoherencetomographydevicesforanteriorchamberanglemeasurements
AT dastiridouanna reproducibilityandagreementbetween2spectraldomainopticalcoherencetomographydevicesforanteriorchamberanglemeasurements
AT zhangzhouyuan reproducibilityandagreementbetween2spectraldomainopticalcoherencetomographydevicesforanteriorchamberanglemeasurements
AT hoalex reproducibilityandagreementbetween2spectraldomainopticalcoherencetomographydevicesforanteriorchamberanglemeasurements
AT francisbriana reproducibilityandagreementbetween2spectraldomainopticalcoherencetomographydevicesforanteriorchamberanglemeasurements
AT saddasrinivasr reproducibilityandagreementbetween2spectraldomainopticalcoherencetomographydevicesforanteriorchamberanglemeasurements
AT chopravikas reproducibilityandagreementbetween2spectraldomainopticalcoherencetomographydevicesforanteriorchamberanglemeasurements