Cargando…

Combination of α-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells

α-Tomatine is a glycoalkaloid found in tomatoes and curcumin is a major yellow pigment of turmeric. In the present study, the combined effect of these two compounds on prostate cancer cells was studied. Treatment of different prostate cancer cells with curcumin or α-tomatine alone resulted in growth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Huarong, Chen, Xuan, Li, Dongli, He, Yan, Li, Yu, Du, Zhiyun, Zhang, Kun, DiPaola, Robert, Goodin, Susan, Zheng, Xi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668011/ https://www.ncbi.nlm.nih.gov/pubmed/26630272 http://dx.doi.org/10.1371/journal.pone.0144293

Ejemplares similares

α-tomatine inhibits growth and induces apoptosis in HL-60 human myeloid leukemia cells
por: HUANG, HUARONG, et al.
Publicado: (2015)

The Effects and Mechanism of YK-4-279 in Combination with Docetaxel on Prostate Cancer
por: Yu, Lin, et al.
Publicado: (2017)

Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo
por: Huang, Huarong, et al.
Publicado: (2014)

Isomers of the Tomato Glycoalkaloids α-Tomatine and Dehydrotomatine: Relationship to Health Benefits
por: Kozukue, Nobuyuki, et al.
Publicado: (2023)

Current Advances in the Biosynthesis, Metabolism, and Transcriptional Regulation of α-Tomatine in Tomato
por: Liu, Yuanyuan, et al.
Publicado: (2023)

Alpha-Tomatine Induces Apoptosis and Inhibits Nuclear Factor-Kappa B Activation on Human Prostatic Adenocarcinoma PC-3 Cells
por: Lee, Sui-Ting, et al.
Publicado: (2011)

Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib
por: WANG, HUAQIAN, et al.
Publicado: (2014)

In Vivo and in vitro antitumor activity of tomatine in hepatocellular carcinoma
por: Echeverría, Cesar, et al.
Publicado: (2022)

Mechanisms of growth inhibition of Phytomonas serpens by the alkaloids tomatine and tomatidine
por: Medina, Jorge Mansur, et al.
Publicado: (2015)

Tomatine Displays Antitumor Potential in In Vitro Models of Metastatic Melanoma
por: Serratì, Simona, et al.
Publicado: (2020)

Biosynthesis, Antibacterial Activity and Anticancer Effects Against Prostate Cancer (PC-3) Cells of Silver Nanoparticles Using Dimocarpus Longan Lour. Peel Extract
por: He, Yan, et al.
Publicado: (2016)

The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2
por: Arena, Mattia P., et al.
Publicado: (2018)

α-Tomatine-Mediated Anti-Cancer Activity In Vitro and In Vivo through Cell Cycle- and Caspase-Independent Pathways
por: Chao, Min-Wu, et al.
Publicado: (2012)

Transdermal estradiol in castrate and chemotherapy resistant prostate cancer
por: Stein, Mark, et al.
Publicado: (2012)

Inhibitory effect of roburic acid in combination with docetaxel on human prostate cancer cells
por: Wang, Xiao, et al.
Publicado: (2022)

The cytotoxic effect of α-tomatine in MCF-7 human adenocarcinoma breast cancer cells depends on its interaction with cholesterol in incubation media and does not involve apoptosis induction
por: SUCHA, LENKA, et al.
Publicado: (2013)

Combination of 12-O-tetradecanoylphorbol-13-acetate with diethyldithiocarbamate markedly inhibits pancreatic cancer cell growth in 3D culture and in immunodeficient mice
por: HUANG, HUARONG, et al.
Publicado: (2015)

Total Phenolic, Flavonoid, Tomatine, and Tomatidine Contents and Antioxidant and Antimicrobial Activities of Extracts of Tomato Plant
por: Silva-Beltrán, Norma Patricia, et al.
Publicado: (2015)

Supramolecular Assembly of Hybrid Pt(II) Porphyrin/Tomatine Analogues with Different Nanostructures and Cytotoxic Activities
por: Fujitsuka, Mayuko, et al.
Publicado: (2021)

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?
por: He, Yan, et al.
Publicado: (2015)

Combination of Lycopene and Curcumin Synergistically Alleviates Testosterone-Propionate-Induced Benign Prostatic Hyperplasia in Sprague Dawley Rats via Modulating Inflammation and Proliferation
por: Wang, Shanshan, et al.
Publicado: (2023)

Inhibitory Effect of a γ-Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice
por: Zheng, Xi, et al.
Publicado: (2011)

RNA-Seq Analyses of Midgut and Fat Body Tissues Reveal the Molecular Mechanism Underlying Spodoptera litura Resistance to Tomatine
por: Li, Qilin, et al.
Publicado: (2019)

Nobiletin, a citrus polymethoxyflavone, enhances the effects of bicalutamide on prostate cancer cells via down regulation of NF-κB, STAT3, and ERK activation
por: Ma, Yuran, et al.
Publicado: (2020)

Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo
por: He, Yan, et al.
Publicado: (2016)

Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2
por: Yue, Wen, et al.
Publicado: (2015)

Celecoxib combined with salirasib strongly inhibits pancreatic cancer cells in 2D and 3D cultures
por: Li, Dongli, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Unsymmetrical Curcumin Analogues as Tyrosinase Inhibitors
por: Jiang, Yongfu, et al.
Publicado: (2013)

Alpha-Tomatine Attenuation of In Vivo Growth of Subcutaneous and Orthotopic Xenograft Tumors of Human Prostate Carcinoma PC-3 Cells Is Accompanied by Inactivation of Nuclear Factor-Kappa B Signaling
por: Lee, Sui-Ting, et al.
Publicado: (2013)

Synergistic effects and mechanisms of impressic acid or acankoreanogein in combination with docetaxel on prostate cancer
por: Jiang, Sen, et al.
Publicado: (2018)

Correction: Alpha-Tomatine Attenuation of In Vivo Growth of Subcutaneous and Orthotopic Xenograft Tumors of Human Prostate Carcinoma PC-3 Cells Is Accompanied by Inactivation of Nuclear Factor-Kappa B Signaling
por: Lee, Sui-Ting, et al.
Publicado: (2022)

Molecular Interactions for the Curcumin-Polymer Complex with Enhanced Anti-Inflammatory Effects
por: He, Yan, et al.
Publicado: (2019)

The Effect and Mechanism of Curcumin Combined with Carboplatin Chemotherapy Promoting on Apoptosis of Lung Cancer HCC827 Cells
por: Huang, Lingping, et al.
Publicado: (2022)

Curcumin Targets Both Apoptosis and Necroptosis in Acidity-Tolerant Prostate Carcinoma Cells
por: Lee, Yoon-Jin, et al.
Publicado: (2021)

Tomatine Adjuvantation of Protective Immunity to a Major Pre-erythrocytic Vaccine Candidate of Malaria is Mediated via CD8(+) T Cell Release of IFN-γ
por: Heal, Karen G., et al.
Publicado: (2010)

Enhancing the Anticancer and Anti-Inflammatory Properties of Curcumin in Combination with Quercetin, for the Prevention and Treatment of Prostate Cancer
por: Pellegrino, Michele, et al.
Publicado: (2023)

Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis
por: Shankar, Sharmila, et al.
Publicado: (2007)

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells
por: Bansal, Nitu, et al.
Publicado: (2015)

Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease
por: Chen, Min, et al.
Publicado: (2018)

Biological Evaluation and 3D-QSAR Studies of Curcumin Analogues as Aldehyde Dehydrogenase 1 Inhibitors
por: Wang, Hui, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_7m69v5i3qg0oroes1evrtrn861