Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

Endothelial senescence plays crucial roles in diabetic vascular complication. Recent evidence indicated that transient hyperglycaemia could potentiate persistent diabetic vascular complications, a phenomenon known as “metabolic memory.” Although SIRT1 has been demonstrated to mediate high glucose-in...

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Detalles Bibliográficos
Autores principales: Zhang, Erli, Guo, Qianyun, Gao, Haiyang, Xu, Ruixia, Teng, Siyong, Wu, Yongjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668014/
https://www.ncbi.nlm.nih.gov/pubmed/26629991
http://dx.doi.org/10.1371/journal.pone.0143814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668014/
https://www.ncbi.nlm.nih.gov/pubmed/26629991
http://dx.doi.org/10.1371/journal.pone.0143814

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