Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine

Varicella zoster virus (VZV) is a highly infectious human herpesvirus that is the causative agent for chicken pox and shingles. VZV encodes a functional thymidylate synthase (TS), which is the sole enzyme that produces dTMP from dUMP de novo. To study substrate binding, the complex structure of TS(V...

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Detalles Bibliográficos
Autores principales: Hew, Kelly, Dahlroth, Sue-Li, Veerappan, Saranya, Pan, Lucy Xin, Cornvik, Tobias, Nordlund, Pär
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668047/
https://www.ncbi.nlm.nih.gov/pubmed/26630264
http://dx.doi.org/10.1371/journal.pone.0143947

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