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Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson’s Disease

BACKGROUND: Preclinical and clinical studies have previously shown that systemic administration of GM1 ganglioside has neuroprotective and neurorestorative properties in Parkinson’s disease (PD) models and in PD patients. However, the clinical development of GM1 for PD has been hampered by its anima...

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Detalles Bibliográficos
Autores principales:	Schneider, Jay S., Seyfried, Thomas N., Choi, Hyo-S., Kidd, Sarah K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668049/ https://www.ncbi.nlm.nih.gov/pubmed/26629687 http://dx.doi.org/10.1371/journal.pone.0143351

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