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TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer

The formation of differentiated cell types from pluripotent progenitors involves epigenetic regulation of gene expression. DNA hydroxymethylation results from the enzymatic oxidation of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) by the ten-eleven translocation (TET) 5-mC dioxygenase...

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Detalles Bibliográficos
Autores principales:	Chapman, Christopher G., Mariani, Christopher J., Wu, Feng, Meckel, Katherine, Butun, Fatma, Chuang, Alice, Madzo, Jozef, Bissonnette, Marc B., Kwon, John H., Godley, Lucy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668370/ https://www.ncbi.nlm.nih.gov/pubmed/26631571 http://dx.doi.org/10.1038/srep17568

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