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β-sitosterol interacts with pneumolysin to prevent Streptococcus pneumoniae infection

Pneumolysin is one of the major virulence factors elaborated by Streptococcus pneumoniae; this toxin is a member of the cholesterol-dependent cytolysins. Engagement of cholesterol induces the formation of a multi-subunit complex by pneumolysin that lyses host cells by forming pores on the membrane....

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Detalles Bibliográficos
Autores principales:	Li, Hongen, Zhao, Xiaoran, Wang, Jianfeng, Dong, Yu, Meng, Song, Li, Rui, Niu, Xiaodi, Deng, Xuming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668377/ https://www.ncbi.nlm.nih.gov/pubmed/26631364 http://dx.doi.org/10.1038/srep17668

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