Profiling of conserved non-coding elements upstream of SHOX and functional characterisation of the SHOX cis-regulatory landscape

Genetic defects such as copy number variations (CNVs) in non-coding regions containing conserved non-coding elements (CNEs) outside the transcription unit of their target gene, can underlie genetic disease. An example of this is the short stature homeobox (SHOX) gene, regulated by seven CNEs located...

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Detalles Bibliográficos
Autores principales: Verdin, Hannah, Fernández-Miñán, Ana, Benito-Sanz, Sara, Janssens, Sandra, Callewaert, Bert, Waele, Kathleen De, Schepper, Jean De, François, Inge, Menten, Björn, Heath, Karen E., Gómez-Skarmeta, José Luis, Baere, Elfride De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668379/
https://www.ncbi.nlm.nih.gov/pubmed/26631348
http://dx.doi.org/10.1038/srep17667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668379/
https://www.ncbi.nlm.nih.gov/pubmed/26631348
http://dx.doi.org/10.1038/srep17667

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