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Fate of HIV-1 cDNA intermediates during reverse transcription is dictated by transcription initiation site of virus genomic RNA
Retroviral reverse transcription is accomplished by sequential strand-transfers of partial cDNA intermediates copied from viral genomic RNA. Here, we revealed an unprecedented role of 5′-end guanosine (G) of HIV-1 genomic RNA for reverse transcription. Based on current consensus for HIV-1 transcript...
Autores principales: | Masuda, Takao, Sato, Yoko, Huang, Yu-Lun, Koi, Satoshi, Takahata, Tatsuro, Hasegawa, Atsuhiko, Kawai, Gota, Kannagi, Mari |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668388/ https://www.ncbi.nlm.nih.gov/pubmed/26631448 http://dx.doi.org/10.1038/srep17680 |
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