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Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation
The transportation of substances in the interstitial space (ISS) is crucial for the maintenance of brain homeostasis, however its link to neuronal activity remains unclear. Here, we report a marked reduction in substance transportation in the ISS after neuronal excitation. Using a tracer-based metho...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668547/ https://www.ncbi.nlm.nih.gov/pubmed/26631412 http://dx.doi.org/10.1038/srep17673 |
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author | Shi, Chunyan Lei, Yiming Han, Hongbin Zuo, Long Yan, Junhao He, Qingyuan Yuan, Lan Liu, Huipo Xu, Ge Xu, Weiguo |
author_facet | Shi, Chunyan Lei, Yiming Han, Hongbin Zuo, Long Yan, Junhao He, Qingyuan Yuan, Lan Liu, Huipo Xu, Ge Xu, Weiguo |
author_sort | Shi, Chunyan |
collection | PubMed |
description | The transportation of substances in the interstitial space (ISS) is crucial for the maintenance of brain homeostasis, however its link to neuronal activity remains unclear. Here, we report a marked reduction in substance transportation in the ISS after neuronal excitation. Using a tracer-based method, water molecules in the interstitial fluid (ISF) could be specifically visualized in magnetic resonance (MR) imaging. We first observed the flow of ISF in the thalamus and caudate nucleus of a rat. The ISF flow was then modulated using a painful stimulation model. We demonstrated that the flow of ISF slowed significantly following neuronal activity in the thalamus. This reduction in ISF flow continued for hours and was not accompanied by slow diffusion into the ISS. This observation suggests that the transportation of substances into the ISS can be regulated with a selective external stimulation. |
format | Online Article Text |
id | pubmed-4668547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46685472015-12-09 Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation Shi, Chunyan Lei, Yiming Han, Hongbin Zuo, Long Yan, Junhao He, Qingyuan Yuan, Lan Liu, Huipo Xu, Ge Xu, Weiguo Sci Rep Article The transportation of substances in the interstitial space (ISS) is crucial for the maintenance of brain homeostasis, however its link to neuronal activity remains unclear. Here, we report a marked reduction in substance transportation in the ISS after neuronal excitation. Using a tracer-based method, water molecules in the interstitial fluid (ISF) could be specifically visualized in magnetic resonance (MR) imaging. We first observed the flow of ISF in the thalamus and caudate nucleus of a rat. The ISF flow was then modulated using a painful stimulation model. We demonstrated that the flow of ISF slowed significantly following neuronal activity in the thalamus. This reduction in ISF flow continued for hours and was not accompanied by slow diffusion into the ISS. This observation suggests that the transportation of substances into the ISS can be regulated with a selective external stimulation. Nature Publishing Group 2015-12-03 /pmc/articles/PMC4668547/ /pubmed/26631412 http://dx.doi.org/10.1038/srep17673 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Shi, Chunyan Lei, Yiming Han, Hongbin Zuo, Long Yan, Junhao He, Qingyuan Yuan, Lan Liu, Huipo Xu, Ge Xu, Weiguo Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation |
title | Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation |
title_full | Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation |
title_fullStr | Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation |
title_full_unstemmed | Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation |
title_short | Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation |
title_sort | transportation in the interstitial space of the brain can be regulated by neuronal excitation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668547/ https://www.ncbi.nlm.nih.gov/pubmed/26631412 http://dx.doi.org/10.1038/srep17673 |
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