Anti-sense DNA d(GGCCCC)(n) expansions in C9ORF72 form i-motifs and protonated hairpins

The G(4)C(2) hexanucleotide repeat expansion mutation (HREM) in C9ORF72, represents the most common mutation associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Three main disease mechanisms have been proposed to date: C9ORF72 haploinsufficiency, RNA tox...

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Detalles Bibliográficos
Autores principales: Kovanda, Anja, Zalar, Matja, Šket, Primož, Plavec, Janez, Rogelj, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668579/
https://www.ncbi.nlm.nih.gov/pubmed/26632347
http://dx.doi.org/10.1038/srep17944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668579/
https://www.ncbi.nlm.nih.gov/pubmed/26632347
http://dx.doi.org/10.1038/srep17944

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