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Anti-sense DNA d(GGCCCC)(n) expansions in C9ORF72 form i-motifs and protonated hairpins
The G(4)C(2) hexanucleotide repeat expansion mutation (HREM) in C9ORF72, represents the most common mutation associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Three main disease mechanisms have been proposed to date: C9ORF72 haploinsufficiency, RNA tox...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668579/ https://www.ncbi.nlm.nih.gov/pubmed/26632347 http://dx.doi.org/10.1038/srep17944 |