Cargando…

Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women

BACKGROUND: Adding testosterone to hormonal therapy could improve sexual function and general well-being among women during climacteric. We evaluated the effectiveness of testosterone undecanoate on sexual function in postmenopausal women utilizing the standardized questionnaire FSFI score. METHODS:...

Descripción completa

Detalles Bibliográficos
Autores principales: Tungmunsakulchai, Reuthairat, Chaikittisilpa, Sukanya, Snabboon, Thiti, Panyakhamlerd, Krasean, Jaisamrarn, Unnop, Taechakraichana, Nimit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668626/
https://www.ncbi.nlm.nih.gov/pubmed/26631095
http://dx.doi.org/10.1186/s12905-015-0270-6
_version_ 1782403998745100288
author Tungmunsakulchai, Reuthairat
Chaikittisilpa, Sukanya
Snabboon, Thiti
Panyakhamlerd, Krasean
Jaisamrarn, Unnop
Taechakraichana, Nimit
author_facet Tungmunsakulchai, Reuthairat
Chaikittisilpa, Sukanya
Snabboon, Thiti
Panyakhamlerd, Krasean
Jaisamrarn, Unnop
Taechakraichana, Nimit
author_sort Tungmunsakulchai, Reuthairat
collection PubMed
description BACKGROUND: Adding testosterone to hormonal therapy could improve sexual function and general well-being among women during climacteric. We evaluated the effectiveness of testosterone undecanoate on sexual function in postmenopausal women utilizing the standardized questionnaire FSFI score. METHODS: Postmenopausal women with sexual complaints and Female Sexual Function Index (FSFI) ≤ 26.5 were enrolled in to this randomized, double-blinded, placebo-controlled trial. Participants were randomly assigned to 8-week treatment with either oral testosterone undecanoate 40 mg or placebo twice weekly with daily oral estrogen. The FSFI scores before and after treatment were compared to assess any improvement of sexual function. RESULTS: Seventy women were recruited of which each group had 35 participants. The baseline characteristics and baseline FSFI scores were comparable between both groups. After 8 weeks of treatment, the FSFI scores significantly improved in both groups when compared to the baseline but the FSFI scores from the testosterone group were significantly higher than in the placebo group post-treatment (28.6 ± 3.6, 25.3 ± 6.7, respectively, p = 0.04). There was no difference in adverse effect between the two groups CONCLUSIONS: The twice weekly addition of testosterone undecanoate to daily oral estrogen was associated with a significant improvement in sexual function among postmenopausal women than the use of the estrogen alone. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT01724658 (February 17, 2012).
format Online
Article
Text
id pubmed-4668626
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-46686262015-12-04 Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women Tungmunsakulchai, Reuthairat Chaikittisilpa, Sukanya Snabboon, Thiti Panyakhamlerd, Krasean Jaisamrarn, Unnop Taechakraichana, Nimit BMC Womens Health Research Article BACKGROUND: Adding testosterone to hormonal therapy could improve sexual function and general well-being among women during climacteric. We evaluated the effectiveness of testosterone undecanoate on sexual function in postmenopausal women utilizing the standardized questionnaire FSFI score. METHODS: Postmenopausal women with sexual complaints and Female Sexual Function Index (FSFI) ≤ 26.5 were enrolled in to this randomized, double-blinded, placebo-controlled trial. Participants were randomly assigned to 8-week treatment with either oral testosterone undecanoate 40 mg or placebo twice weekly with daily oral estrogen. The FSFI scores before and after treatment were compared to assess any improvement of sexual function. RESULTS: Seventy women were recruited of which each group had 35 participants. The baseline characteristics and baseline FSFI scores were comparable between both groups. After 8 weeks of treatment, the FSFI scores significantly improved in both groups when compared to the baseline but the FSFI scores from the testosterone group were significantly higher than in the placebo group post-treatment (28.6 ± 3.6, 25.3 ± 6.7, respectively, p = 0.04). There was no difference in adverse effect between the two groups CONCLUSIONS: The twice weekly addition of testosterone undecanoate to daily oral estrogen was associated with a significant improvement in sexual function among postmenopausal women than the use of the estrogen alone. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT01724658 (February 17, 2012). BioMed Central 2015-12-02 /pmc/articles/PMC4668626/ /pubmed/26631095 http://dx.doi.org/10.1186/s12905-015-0270-6 Text en © Tungmunsakulchai et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Tungmunsakulchai, Reuthairat
Chaikittisilpa, Sukanya
Snabboon, Thiti
Panyakhamlerd, Krasean
Jaisamrarn, Unnop
Taechakraichana, Nimit
Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women
title Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women
title_full Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women
title_fullStr Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women
title_full_unstemmed Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women
title_short Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women
title_sort effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668626/
https://www.ncbi.nlm.nih.gov/pubmed/26631095
http://dx.doi.org/10.1186/s12905-015-0270-6
work_keys_str_mv AT tungmunsakulchaireuthairat effectivenessofalowdosetestosteroneundecanoatetoimprovesexualfunctioninpostmenopausalwomen
AT chaikittisilpasukanya effectivenessofalowdosetestosteroneundecanoatetoimprovesexualfunctioninpostmenopausalwomen
AT snabboonthiti effectivenessofalowdosetestosteroneundecanoatetoimprovesexualfunctioninpostmenopausalwomen
AT panyakhamlerdkrasean effectivenessofalowdosetestosteroneundecanoatetoimprovesexualfunctioninpostmenopausalwomen
AT jaisamrarnunnop effectivenessofalowdosetestosteroneundecanoatetoimprovesexualfunctioninpostmenopausalwomen
AT taechakraichananimit effectivenessofalowdosetestosteroneundecanoatetoimprovesexualfunctioninpostmenopausalwomen