Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the ep...

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Autores principales: Xu, Xin, Lu, Linlin, Dong, Quanyong, Li, Xiaolin, Zhang, Nannan, Xin, Yongning, Xuan, Shiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668687/
https://www.ncbi.nlm.nih.gov/pubmed/26631018
http://dx.doi.org/10.1186/s12944-015-0141-z
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author Xu, Xin
Lu, Linlin
Dong, Quanyong
Li, Xiaolin
Zhang, Nannan
Xin, Yongning
Xuan, Shiying
author_facet Xu, Xin
Lu, Linlin
Dong, Quanyong
Li, Xiaolin
Zhang, Nannan
Xin, Yongning
Xuan, Shiying
author_sort Xu, Xin
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.
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spelling pubmed-46686872015-12-04 Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis Xu, Xin Lu, Linlin Dong, Quanyong Li, Xiaolin Zhang, Nannan Xin, Yongning Xuan, Shiying Lipids Health Dis Review Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them. BioMed Central 2015-12-03 /pmc/articles/PMC4668687/ /pubmed/26631018 http://dx.doi.org/10.1186/s12944-015-0141-z Text en © Xu et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Xu, Xin
Lu, Linlin
Dong, Quanyong
Li, Xiaolin
Zhang, Nannan
Xin, Yongning
Xuan, Shiying
Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis
title Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis
title_full Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis
title_fullStr Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis
title_full_unstemmed Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis
title_short Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis
title_sort research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668687/
https://www.ncbi.nlm.nih.gov/pubmed/26631018
http://dx.doi.org/10.1186/s12944-015-0141-z
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