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Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer
The retinoblastoma gene (Rb) is mutated at significant frequency in various human epithelial tumors, including colorectal cancer, and is strongly associated with metastatic disease. However, sole inactivation of Rb in the mouse has so far failed to yield epithelial cancers. Here, we specifically ina...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668801/ https://www.ncbi.nlm.nih.gov/pubmed/25745996 http://dx.doi.org/10.1038/onc.2015.30 |