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Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury
INTRODUCTION: Various neuroregenerative procedures have been recently employed along with neurorehabilitation programs to promote neurological function after Spinal Cord Injury (SCI), and recently most of them have focused on the acute stage of spinal cord injury. In this report, we present a case o...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Neuroscience Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668877/ https://www.ncbi.nlm.nih.gov/pubmed/26649168 |
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author | Derakhshanrad, Nazi Saberi, Hooshang Tayebi Meybodi, Keyvan Taghvaei, Mohammad Arjmand, Babak Aghayan, Hamid Reza Kohan, Amir Hassan Haghpanahi, Mohammad Rahmani, Shahrokh |
author_facet | Derakhshanrad, Nazi Saberi, Hooshang Tayebi Meybodi, Keyvan Taghvaei, Mohammad Arjmand, Babak Aghayan, Hamid Reza Kohan, Amir Hassan Haghpanahi, Mohammad Rahmani, Shahrokh |
author_sort | Derakhshanrad, Nazi |
collection | PubMed |
description | INTRODUCTION: Various neuroregenerative procedures have been recently employed along with neurorehabilitation programs to promote neurological function after Spinal Cord Injury (SCI), and recently most of them have focused on the acute stage of spinal cord injury. In this report, we present a case of acute SCI treated with neuroprotective treatments in conjunction with conventional rehabilitation program. METHODS: A case of acute penetrative SCI (gunshot wound), 40 years old, was treated with intrathecal bone marrow derived stem cells and parenteral Granulocyte-Colony Stimulating Factor (G-CSF) along with rehabilitation program. The neurological outcomes as well as safety issues have been reported. RESULTS: Assessment with American Spinal Injury Association (ASIA), showed neurological improvement, meanwhile he reported neuropathic pain, which was amenable to oral medication. DISCUSSION: In the acute setting, combination therapy of G-CSF and intrathecal Mesenchymal Stem Cells (MSCs) was safe in our case as an adjunct to conventional rehabilitation programs. Further controlled studies are needed to find possible side effects, and establish net efficacy. |
format | Online Article Text |
id | pubmed-4668877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Iranian Neuroscience Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-46688772015-12-08 Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury Derakhshanrad, Nazi Saberi, Hooshang Tayebi Meybodi, Keyvan Taghvaei, Mohammad Arjmand, Babak Aghayan, Hamid Reza Kohan, Amir Hassan Haghpanahi, Mohammad Rahmani, Shahrokh Basic Clin Neurosci Case Report INTRODUCTION: Various neuroregenerative procedures have been recently employed along with neurorehabilitation programs to promote neurological function after Spinal Cord Injury (SCI), and recently most of them have focused on the acute stage of spinal cord injury. In this report, we present a case of acute SCI treated with neuroprotective treatments in conjunction with conventional rehabilitation program. METHODS: A case of acute penetrative SCI (gunshot wound), 40 years old, was treated with intrathecal bone marrow derived stem cells and parenteral Granulocyte-Colony Stimulating Factor (G-CSF) along with rehabilitation program. The neurological outcomes as well as safety issues have been reported. RESULTS: Assessment with American Spinal Injury Association (ASIA), showed neurological improvement, meanwhile he reported neuropathic pain, which was amenable to oral medication. DISCUSSION: In the acute setting, combination therapy of G-CSF and intrathecal Mesenchymal Stem Cells (MSCs) was safe in our case as an adjunct to conventional rehabilitation programs. Further controlled studies are needed to find possible side effects, and establish net efficacy. Iranian Neuroscience Society 2015-10 /pmc/articles/PMC4668877/ /pubmed/26649168 Text en Copyright© 2015 Iranian Neuroscience Society This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Case Report Derakhshanrad, Nazi Saberi, Hooshang Tayebi Meybodi, Keyvan Taghvaei, Mohammad Arjmand, Babak Aghayan, Hamid Reza Kohan, Amir Hassan Haghpanahi, Mohammad Rahmani, Shahrokh Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury |
title | Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury |
title_full | Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury |
title_fullStr | Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury |
title_full_unstemmed | Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury |
title_short | Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury |
title_sort | case report: combination therapy with mesenchymal stem cells and granulocyte-colony stimulating factor in a case of spinal cord injury |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668877/ https://www.ncbi.nlm.nih.gov/pubmed/26649168 |
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