Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release

A novel Uralic (U)-rich linear-hyperbranched mono-methoxy poly (ethylene glycol)-hyperbranched polyglycerol-graft-Uralic (mPEG-HPG-g-U) nanoparticle (NP) was prepared as drug carrier for antitumor methotrexate (MTX). Due to the H-bond interaction of U with MTX and hydrophobic interaction, this NP ex...

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Autores principales: Cai, Teng-Teng, Lei, Qi, Yang, Bin, Jia, Hui-Zhen, Cheng, Hong, Liu, Li-Han, Zeng, Xuan, Feng, Jun, Zhuo, Ren-Xi, Zhang, Xian-Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669001/
https://www.ncbi.nlm.nih.gov/pubmed/26816622
http://dx.doi.org/10.1093/rb/rbu010
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author Cai, Teng-Teng
Lei, Qi
Yang, Bin
Jia, Hui-Zhen
Cheng, Hong
Liu, Li-Han
Zeng, Xuan
Feng, Jun
Zhuo, Ren-Xi
Zhang, Xian-Zheng
author_facet Cai, Teng-Teng
Lei, Qi
Yang, Bin
Jia, Hui-Zhen
Cheng, Hong
Liu, Li-Han
Zeng, Xuan
Feng, Jun
Zhuo, Ren-Xi
Zhang, Xian-Zheng
author_sort Cai, Teng-Teng
collection PubMed
description A novel Uralic (U)-rich linear-hyperbranched mono-methoxy poly (ethylene glycol)-hyperbranched polyglycerol-graft-Uralic (mPEG-HPG-g-U) nanoparticle (NP) was prepared as drug carrier for antitumor methotrexate (MTX). Due to the H-bond interaction of U with MTX and hydrophobic interaction, this NP exhibited high drug loading efficiency of up to 40%, which was significantly higher than that of traditional NPs based on U-absent copolymers (<15%). In addition, MTX-loaded mPEG-HPG-g-U NPs also demonstrated an acidity-accelerated drug release behavior.
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spelling pubmed-46690012016-01-26 Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release Cai, Teng-Teng Lei, Qi Yang, Bin Jia, Hui-Zhen Cheng, Hong Liu, Li-Han Zeng, Xuan Feng, Jun Zhuo, Ren-Xi Zhang, Xian-Zheng Regen Biomater Research Articles A novel Uralic (U)-rich linear-hyperbranched mono-methoxy poly (ethylene glycol)-hyperbranched polyglycerol-graft-Uralic (mPEG-HPG-g-U) nanoparticle (NP) was prepared as drug carrier for antitumor methotrexate (MTX). Due to the H-bond interaction of U with MTX and hydrophobic interaction, this NP exhibited high drug loading efficiency of up to 40%, which was significantly higher than that of traditional NPs based on U-absent copolymers (<15%). In addition, MTX-loaded mPEG-HPG-g-U NPs also demonstrated an acidity-accelerated drug release behavior. Oxford University Press 2014-11 2014-10-20 /pmc/articles/PMC4669001/ /pubmed/26816622 http://dx.doi.org/10.1093/rb/rbu010 Text en © The Author(s) 2014. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Cai, Teng-Teng
Lei, Qi
Yang, Bin
Jia, Hui-Zhen
Cheng, Hong
Liu, Li-Han
Zeng, Xuan
Feng, Jun
Zhuo, Ren-Xi
Zhang, Xian-Zheng
Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release
title Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release
title_full Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release
title_fullStr Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release
title_full_unstemmed Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release
title_short Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release
title_sort utilization of h-bond interaction of nucleobase uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and ph-responsive drug release
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669001/
https://www.ncbi.nlm.nih.gov/pubmed/26816622
http://dx.doi.org/10.1093/rb/rbu010
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