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Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ(9)-Tetrahydrocannabinol

OBJECTIVE: Acute administration of cannabinoid CB(1) receptor agonists, or the ingestion of cannabis, induces short-term hyperphagia. However, the incidence of obesity is lower in frequent cannabis users compared to non-users. Gut microbiota affects host metabolism and altered microbial profiles are...

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Autores principales: Cluny, Nina L., Keenan, Catherine M., Reimer, Raylene A., Le Foll, Bernard, Sharkey, Keith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669115/
https://www.ncbi.nlm.nih.gov/pubmed/26633823
http://dx.doi.org/10.1371/journal.pone.0144270
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author Cluny, Nina L.
Keenan, Catherine M.
Reimer, Raylene A.
Le Foll, Bernard
Sharkey, Keith A.
author_facet Cluny, Nina L.
Keenan, Catherine M.
Reimer, Raylene A.
Le Foll, Bernard
Sharkey, Keith A.
author_sort Cluny, Nina L.
collection PubMed
description OBJECTIVE: Acute administration of cannabinoid CB(1) receptor agonists, or the ingestion of cannabis, induces short-term hyperphagia. However, the incidence of obesity is lower in frequent cannabis users compared to non-users. Gut microbiota affects host metabolism and altered microbial profiles are observed in obese states. Gut microbiota modifies adipogenesis through actions on the endocannabinoid system. This study investigated the effect of chronic THC administration on body weight and gut microbiota in diet-induced obese (DIO) and lean mice. METHODS: Adult male DIO and lean mice were treated daily with vehicle or THC (2mg/kg for 3 weeks and 4 mg/kg for 1 additional week). Body weight, fat mass, energy intake, locomotor activity, whole gut transit and gut microbiota were measured longitudinally. RESULTS: THC reduced weight gain, fat mass gain and energy intake in DIO but not lean mice. DIO-induced changes in select gut microbiota were prevented in mice chronically administered THC. THC had no effect on locomotor activity or whole gut transit in either lean or DIO mice. CONCLUSIONS: Chronic THC treatment reduced energy intake and prevented high fat diet-induced increases in body weight and adiposity; effects that were unlikely to be a result of sedation or altered gastrointestinal transit. Changes in gut microbiota potentially contribute to chronic THC-induced actions on body weight in obesity.
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spelling pubmed-46691152015-12-10 Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ(9)-Tetrahydrocannabinol Cluny, Nina L. Keenan, Catherine M. Reimer, Raylene A. Le Foll, Bernard Sharkey, Keith A. PLoS One Research Article OBJECTIVE: Acute administration of cannabinoid CB(1) receptor agonists, or the ingestion of cannabis, induces short-term hyperphagia. However, the incidence of obesity is lower in frequent cannabis users compared to non-users. Gut microbiota affects host metabolism and altered microbial profiles are observed in obese states. Gut microbiota modifies adipogenesis through actions on the endocannabinoid system. This study investigated the effect of chronic THC administration on body weight and gut microbiota in diet-induced obese (DIO) and lean mice. METHODS: Adult male DIO and lean mice were treated daily with vehicle or THC (2mg/kg for 3 weeks and 4 mg/kg for 1 additional week). Body weight, fat mass, energy intake, locomotor activity, whole gut transit and gut microbiota were measured longitudinally. RESULTS: THC reduced weight gain, fat mass gain and energy intake in DIO but not lean mice. DIO-induced changes in select gut microbiota were prevented in mice chronically administered THC. THC had no effect on locomotor activity or whole gut transit in either lean or DIO mice. CONCLUSIONS: Chronic THC treatment reduced energy intake and prevented high fat diet-induced increases in body weight and adiposity; effects that were unlikely to be a result of sedation or altered gastrointestinal transit. Changes in gut microbiota potentially contribute to chronic THC-induced actions on body weight in obesity. Public Library of Science 2015-12-03 /pmc/articles/PMC4669115/ /pubmed/26633823 http://dx.doi.org/10.1371/journal.pone.0144270 Text en © 2015 Cluny et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Cluny, Nina L.
Keenan, Catherine M.
Reimer, Raylene A.
Le Foll, Bernard
Sharkey, Keith A.
Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ(9)-Tetrahydrocannabinol
title Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ(9)-Tetrahydrocannabinol
title_full Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ(9)-Tetrahydrocannabinol
title_fullStr Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ(9)-Tetrahydrocannabinol
title_full_unstemmed Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ(9)-Tetrahydrocannabinol
title_short Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ(9)-Tetrahydrocannabinol
title_sort prevention of diet-induced obesity effects on body weight and gut microbiota in mice treated chronically with δ(9)-tetrahydrocannabinol
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669115/
https://www.ncbi.nlm.nih.gov/pubmed/26633823
http://dx.doi.org/10.1371/journal.pone.0144270
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