Randomized Controlled Trial of Zoledronic Acid plus Chemotherapy versus Chemotherapy Alone as Neoadjuvant Treatment of HER2-Negative Primary Breast Cancer (JONIE Study)

PURPOSE: Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate that induces osteoclast apoptosis and inhibits bone resorption by inhibiting the mevalonate pathway. Its benefit for the prevention of skeletal complications due to bone metastases has been established. However, the antitumor eff...

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Detalles Bibliográficos
Autores principales: Hasegawa, Yoshie, Tanino, Hirokazu, Horiguchi, Jun, Miura, Daishu, Ishikawa, Takashi, Hayashi, Mitsuhiro, Takao, Shintaro, Kim, Seung Jin, Yamagami, Kazuhiko, Miyashita, Masaru, Konishi, Muneharu, Shigeoka, Yasushi, Suzuki, Masato, Taguchi, Tetsuya, Kubota, Tomoyuki, Akazawa, Kouhei, Kohno, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669153/
https://www.ncbi.nlm.nih.gov/pubmed/26633806
http://dx.doi.org/10.1371/journal.pone.0143643

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