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Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a multi-functional cytokine, which is involved in the pathophysiological processes of cardiovascular and metabolic diseases. Previously, we demonstrated that TRAIL stimulated lipid uptake and foam cell formation in macrophages in vit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669162/ https://www.ncbi.nlm.nih.gov/pubmed/26633016 http://dx.doi.org/10.1371/journal.pone.0144015 |
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author | Cheng, Wen Liu, Fangfang Wang, Zhe Zhang, Yun Zhao, Yu-Xia Zhang, Qunye Jiang, Fan |
author_facet | Cheng, Wen Liu, Fangfang Wang, Zhe Zhang, Yun Zhao, Yu-Xia Zhang, Qunye Jiang, Fan |
author_sort | Cheng, Wen |
collection | PubMed |
description | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a multi-functional cytokine, which is involved in the pathophysiological processes of cardiovascular and metabolic diseases. Previously, we demonstrated that TRAIL stimulated lipid uptake and foam cell formation in macrophages in vitro. Several clinical studies have suggested that the serum concentration of TRAIL may be increased in humans with elevated blood cholesterol; however, the current data appear to be inconclusive in this regard. In the present study, we examined the relationships between the serum TRAIL concentration and cholesterol levels in 352 generally healthy subjects undergoing the routine annual health check. We showed that there were significant correlations between TRAIL concentration and levels of total and low-density lipoprotein cholesterols. The level of TRAIL was significantly elevated in subjects with hypercholesterolemia, although this relationship might be also associated with changes of other metabolic factors. Moreover, we showed that the level of blood cholesterol was significantly higher in subjects in the upper quartile of serum TRAIL. In conclusion, our data demonstrate that the serum TRAIL concentration is elevated in people with hypercholesterolemia. |
format | Online Article Text |
id | pubmed-4669162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46691622015-12-10 Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia Cheng, Wen Liu, Fangfang Wang, Zhe Zhang, Yun Zhao, Yu-Xia Zhang, Qunye Jiang, Fan PLoS One Research Article Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a multi-functional cytokine, which is involved in the pathophysiological processes of cardiovascular and metabolic diseases. Previously, we demonstrated that TRAIL stimulated lipid uptake and foam cell formation in macrophages in vitro. Several clinical studies have suggested that the serum concentration of TRAIL may be increased in humans with elevated blood cholesterol; however, the current data appear to be inconclusive in this regard. In the present study, we examined the relationships between the serum TRAIL concentration and cholesterol levels in 352 generally healthy subjects undergoing the routine annual health check. We showed that there were significant correlations between TRAIL concentration and levels of total and low-density lipoprotein cholesterols. The level of TRAIL was significantly elevated in subjects with hypercholesterolemia, although this relationship might be also associated with changes of other metabolic factors. Moreover, we showed that the level of blood cholesterol was significantly higher in subjects in the upper quartile of serum TRAIL. In conclusion, our data demonstrate that the serum TRAIL concentration is elevated in people with hypercholesterolemia. Public Library of Science 2015-12-03 /pmc/articles/PMC4669162/ /pubmed/26633016 http://dx.doi.org/10.1371/journal.pone.0144015 Text en © 2015 Cheng et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Cheng, Wen Liu, Fangfang Wang, Zhe Zhang, Yun Zhao, Yu-Xia Zhang, Qunye Jiang, Fan Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia |
title | Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia |
title_full | Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia |
title_fullStr | Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia |
title_full_unstemmed | Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia |
title_short | Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia |
title_sort | soluble trail concentration in serum is elevated in people with hypercholesterolemia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669162/ https://www.ncbi.nlm.nih.gov/pubmed/26633016 http://dx.doi.org/10.1371/journal.pone.0144015 |
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