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Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI
Language reorganisation following stroke has been studied widely. However, while studies of brain activation and grey matter examined both hemispheres, studies of white matter changes have mostly focused on the left hemisphere. Here we examined the relationship between bilateral hemispheric white ma...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669306/ https://www.ncbi.nlm.nih.gov/pubmed/26401977 http://dx.doi.org/10.1016/j.bandl.2015.09.001 |
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author | Geva, Sharon Correia, Marta M. Warburton, Elizabeth A. |
author_facet | Geva, Sharon Correia, Marta M. Warburton, Elizabeth A. |
author_sort | Geva, Sharon |
collection | PubMed |
description | Language reorganisation following stroke has been studied widely. However, while studies of brain activation and grey matter examined both hemispheres, studies of white matter changes have mostly focused on the left hemisphere. Here we examined the relationship between bilateral hemispheric white matter and aphasia symptoms. 15 chronic stroke patients with aphasia and 18 healthy adults were studied using Diffusion Weighted Imaging data. By applying histogram analysis, Tract-Based Spatial Statistics, tractography and lesion-tract overlap methods, it was found that damage to the left hemisphere in general, and to the arcuate fasciculus in particular, correlated with impairments on word repetition, object naming, sentence comprehension and homophone and rhyme judgement. However, no such relationship was found in the right hemisphere. It is suggested that while some language function in aphasia can be explained by damage to the left arcuate fasciculus, it cannot be explained by looking at the contra-lesional tract. |
format | Online Article Text |
id | pubmed-4669306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46693062015-12-23 Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI Geva, Sharon Correia, Marta M. Warburton, Elizabeth A. Brain Lang Article Language reorganisation following stroke has been studied widely. However, while studies of brain activation and grey matter examined both hemispheres, studies of white matter changes have mostly focused on the left hemisphere. Here we examined the relationship between bilateral hemispheric white matter and aphasia symptoms. 15 chronic stroke patients with aphasia and 18 healthy adults were studied using Diffusion Weighted Imaging data. By applying histogram analysis, Tract-Based Spatial Statistics, tractography and lesion-tract overlap methods, it was found that damage to the left hemisphere in general, and to the arcuate fasciculus in particular, correlated with impairments on word repetition, object naming, sentence comprehension and homophone and rhyme judgement. However, no such relationship was found in the right hemisphere. It is suggested that while some language function in aphasia can be explained by damage to the left arcuate fasciculus, it cannot be explained by looking at the contra-lesional tract. Academic Press 2015-11 /pmc/articles/PMC4669306/ /pubmed/26401977 http://dx.doi.org/10.1016/j.bandl.2015.09.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Geva, Sharon Correia, Marta M. Warburton, Elizabeth A. Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI |
title | Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI |
title_full | Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI |
title_fullStr | Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI |
title_full_unstemmed | Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI |
title_short | Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI |
title_sort | contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor mri |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669306/ https://www.ncbi.nlm.nih.gov/pubmed/26401977 http://dx.doi.org/10.1016/j.bandl.2015.09.001 |
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