Fabrication and in vivo evaluation of Nelfinavir loaded PLGA nanoparticles for enhancing oral bioavailability and therapeutic effect

Nelfinavir mesylate (NFV) is an anti-viral drug, used in the treatment of Acquired Immunodeficiency Syndrome (AIDS). Poor oral bioavailability and shorter half-life (3.5–5 h) remain a major clinical limitation of NFV leading to unpredictable drug bioavailability and frequent dosing. In this context,...

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Detalles Bibliográficos
Autores principales: Venkatesh, D. Nagasamy, Baskaran, Mahendran, Karri, Veera Venkata Satyanarayana Reddy, Mannemala, Sai Sandeep, Radhakrishna, Kollipara, Goti, Sandip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669422/
https://www.ncbi.nlm.nih.gov/pubmed/26702262
http://dx.doi.org/10.1016/j.jsps.2015.02.021

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