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Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China

As a multi-ethnic country, China has some indigenous population groups which vary in culture and social customs, perhaps as a result of geographic isolation and different traditions. However, upon close interactions and intermarriage, admixture of different gene pools among these ethnic groups may o...

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Autores principales: Zhang, Suhua, Bian, Yingnan, Li, Li, Sun, Kuan, wang, Zheng, Zhao, Qi, Zha, Lagabaiyila, Cai, Jifeng, Gao, Yuzhen, Ji, Chaoneng, Li, Chengtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669481/
https://www.ncbi.nlm.nih.gov/pubmed/26634331
http://dx.doi.org/10.1038/srep17711
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author Zhang, Suhua
Bian, Yingnan
Li, Li
Sun, Kuan
wang, Zheng
Zhao, Qi
Zha, Lagabaiyila
Cai, Jifeng
Gao, Yuzhen
Ji, Chaoneng
Li, Chengtao
author_facet Zhang, Suhua
Bian, Yingnan
Li, Li
Sun, Kuan
wang, Zheng
Zhao, Qi
Zha, Lagabaiyila
Cai, Jifeng
Gao, Yuzhen
Ji, Chaoneng
Li, Chengtao
author_sort Zhang, Suhua
collection PubMed
description As a multi-ethnic country, China has some indigenous population groups which vary in culture and social customs, perhaps as a result of geographic isolation and different traditions. However, upon close interactions and intermarriage, admixture of different gene pools among these ethnic groups may occur. In order to gain more insight on the genetic background of X-Chromosome from these ethnic groups, a set of X-markers (18 X-STRs and 16 X-Indels) was genotyped in 5 main ethnic groups of China (HAN, HUI, Uygur, Mongolian, Tibetan). Twenty-three private alleles were detected in HAN, Uygur, Tibetan and Mongolian. Significant differences (p < 0.0001) were all observed for the 3 parameters of heterozygosity (Ho, He and UHe) among the 5 ethnic groups. Highest values of Nei genetic distance were always observed at HUI-Uygur pairwise when analyzed with X-STRs or X-Indels separately and combined. Phylogenetic tree and PCA analyses revealed a clear pattern of population differentiation of HUI and Uygur. However, the HAN, Tibetan and Mongolian ethnic groups were closely clustered. Eighteen X-Indels exhibited in general congruent phylogenetic signal and similar cluster among the 5 ethnic groups compared with 16 X-STRs. Aforementioned results proved the genetic polymorphism and potential of the 34 X-markers in the 5 ethnic groups.
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spelling pubmed-46694812015-12-11 Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China Zhang, Suhua Bian, Yingnan Li, Li Sun, Kuan wang, Zheng Zhao, Qi Zha, Lagabaiyila Cai, Jifeng Gao, Yuzhen Ji, Chaoneng Li, Chengtao Sci Rep Article As a multi-ethnic country, China has some indigenous population groups which vary in culture and social customs, perhaps as a result of geographic isolation and different traditions. However, upon close interactions and intermarriage, admixture of different gene pools among these ethnic groups may occur. In order to gain more insight on the genetic background of X-Chromosome from these ethnic groups, a set of X-markers (18 X-STRs and 16 X-Indels) was genotyped in 5 main ethnic groups of China (HAN, HUI, Uygur, Mongolian, Tibetan). Twenty-three private alleles were detected in HAN, Uygur, Tibetan and Mongolian. Significant differences (p < 0.0001) were all observed for the 3 parameters of heterozygosity (Ho, He and UHe) among the 5 ethnic groups. Highest values of Nei genetic distance were always observed at HUI-Uygur pairwise when analyzed with X-STRs or X-Indels separately and combined. Phylogenetic tree and PCA analyses revealed a clear pattern of population differentiation of HUI and Uygur. However, the HAN, Tibetan and Mongolian ethnic groups were closely clustered. Eighteen X-Indels exhibited in general congruent phylogenetic signal and similar cluster among the 5 ethnic groups compared with 16 X-STRs. Aforementioned results proved the genetic polymorphism and potential of the 34 X-markers in the 5 ethnic groups. Nature Publishing Group 2015-12-04 /pmc/articles/PMC4669481/ /pubmed/26634331 http://dx.doi.org/10.1038/srep17711 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Suhua
Bian, Yingnan
Li, Li
Sun, Kuan
wang, Zheng
Zhao, Qi
Zha, Lagabaiyila
Cai, Jifeng
Gao, Yuzhen
Ji, Chaoneng
Li, Chengtao
Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China
title Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China
title_full Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China
title_fullStr Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China
title_full_unstemmed Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China
title_short Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China
title_sort population genetic study of 34 x-chromosome markers in 5 main ethnic groups of china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669481/
https://www.ncbi.nlm.nih.gov/pubmed/26634331
http://dx.doi.org/10.1038/srep17711
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